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All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.

Publication ,  Journal Article
Yang, J; Kornbluth, S
Published in: Trends in cell biology
June 1999

Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK-cyclins). Although the enzymatic activity of these complexes is regulated tightly, it has recently been demonstrated that an additional facet of cell-cycle control involves the modulation of CDK-cyclin subcellular localization. Recent discoveries include the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus, the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDK-cyclin subcellular localization.

Duke Scholars

Published In

Trends in cell biology

DOI

EISSN

1879-3088

ISSN

0962-8924

Publication Date

June 1999

Volume

9

Issue

6

Start / End Page

207 / 210

Related Subject Headings

  • S Phase
  • Mitosis
  • Humans
  • G2 Phase
  • G1 Phase
  • Developmental Biology
  • Cytoplasm
  • Cyclins
  • Cyclin-Dependent Kinases
  • Cell Nucleus
 

Citation

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Yang, J., & Kornbluth, S. (1999). All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. Trends in Cell Biology, 9(6), 207–210. https://doi.org/10.1016/s0962-8924(99)01577-9
Yang, J., and S. Kornbluth. “All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.Trends in Cell Biology 9, no. 6 (June 1999): 207–10. https://doi.org/10.1016/s0962-8924(99)01577-9.
Yang J, Kornbluth S. All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. Trends in cell biology. 1999 Jun;9(6):207–10.
Yang, J., and S. Kornbluth. “All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.Trends in Cell Biology, vol. 9, no. 6, June 1999, pp. 207–10. Epmc, doi:10.1016/s0962-8924(99)01577-9.
Yang J, Kornbluth S. All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. Trends in cell biology. 1999 Jun;9(6):207–210.
Journal cover image

Published In

Trends in cell biology

DOI

EISSN

1879-3088

ISSN

0962-8924

Publication Date

June 1999

Volume

9

Issue

6

Start / End Page

207 / 210

Related Subject Headings

  • S Phase
  • Mitosis
  • Humans
  • G2 Phase
  • G1 Phase
  • Developmental Biology
  • Cytoplasm
  • Cyclins
  • Cyclin-Dependent Kinases
  • Cell Nucleus