Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.
Publication
, Journal Article
Seitan, VC; Krangel, MS; Merkenschlager, M
Published in: Trends Immunol
April 2012
The somatic recombination of lymphocyte antigen receptor loci is integral to lymphocyte differentiation and adaptive immunity. Here we review the relation of this highly choreographed process with the zinc finger protein CTCF and with cohesin, a protein complex best known for its essential functions in post-replicative DNA repair and chromosome segregation during the cell cycle. At lymphocyte antigen receptor loci, CTCF and cohesin shape long-range interactions and contribute to V(D)J recombination by facilitating lineage- and developmental-stage-specific transcription and accessibility.
Duke Scholars
Published In
Trends Immunol
DOI
EISSN
1471-4981
Publication Date
April 2012
Volume
33
Issue
4
Start / End Page
153 / 159
Location
England
Related Subject Headings
- V(D)J Recombination
- Transcription, Genetic
- Repressor Proteins
- Immunology
- Humans
- Genetic Loci
- Gene Rearrangement, T-Lymphocyte
- Cohesins
- Chromosomal Proteins, Non-Histone
- Cell Cycle Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Seitan, V. C., Krangel, M. S., & Merkenschlager, M. (2012). Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. Trends Immunol, 33(4), 153–159. https://doi.org/10.1016/j.it.2012.02.004
Seitan, Vlad C., Michael S. Krangel, and Matthias Merkenschlager. “Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.” Trends Immunol 33, no. 4 (April 2012): 153–59. https://doi.org/10.1016/j.it.2012.02.004.
Seitan VC, Krangel MS, Merkenschlager M. Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. Trends Immunol. 2012 Apr;33(4):153–9.
Seitan, Vlad C., et al. “Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.” Trends Immunol, vol. 33, no. 4, Apr. 2012, pp. 153–59. Pubmed, doi:10.1016/j.it.2012.02.004.
Seitan VC, Krangel MS, Merkenschlager M. Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. Trends Immunol. 2012 Apr;33(4):153–159.
Published In
Trends Immunol
DOI
EISSN
1471-4981
Publication Date
April 2012
Volume
33
Issue
4
Start / End Page
153 / 159
Location
England
Related Subject Headings
- V(D)J Recombination
- Transcription, Genetic
- Repressor Proteins
- Immunology
- Humans
- Genetic Loci
- Gene Rearrangement, T-Lymphocyte
- Cohesins
- Chromosomal Proteins, Non-Histone
- Cell Cycle Proteins