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Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women.

Publication ,  Journal Article
Nicklas, BJ; Leng, I; Delbono, O; Kitzman, DW; Marsh, AP; Hundley, WG; Lyles, MF; O'Rourke, KS; Annex, BH; Kraus, WE
Published in: Aging Clin Exp Res
August 2008

BACKGROUND AND AIMS: There are no data showing whether or not age-related declines in physical function are related to in vitro properties of human skeletal muscle. The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults. METHODS: The study was a cross-sectional observational study of 39 sedentary, older (60-85 yrs) men and women. A needle biopsy of the vastus lateralis for assessment of muscle fiber type, fiber area, capillary density and citrate synthase and aldolase activities was performed. Physical function tests included the Short Physical Performance Battery (balance, walking speed, and chair rise time), as well as self-reported disability. RESULTS: Total fiber area (R=-0.41, p=0.02), number of Type II fibers (R=-0.33, p=0.05), and aldolase activity (R=-0.54, p=0.01) were inversely related to age. Persons who reported greater difficulty with daily activities had lower capillary density (R=-0.51, p=0.03) and lower citrate synthase activity (R=-0.66, p=0.03). Walking speed was directly related to fiber area (R=0.40, p=0.02), capillary density (R=0.39, p=0.03), citrate synthase (R=0.45, p=0.03) and aldolase (R=0.55, p<0.01) activities, even after adjustment for age, BMI and disease status. CONCLUSIONS: In older adults, skeletal muscle capillary density and metabolic enzymatic activity are independent predictors of lower extremity physical function.

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Published In

Aging Clin Exp Res

DOI

ISSN

1594-0667

Publication Date

August 2008

Volume

20

Issue

4

Start / End Page

302 / 309

Location

Germany

Related Subject Headings

  • Quadriceps Muscle
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Female
  • Capillaries
  • Body Mass Index
  • Aged, 80 and over
  • Aged
 

Citation

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ICMJE
MLA
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Nicklas, B. J., Leng, I., Delbono, O., Kitzman, D. W., Marsh, A. P., Hundley, W. G., … Kraus, W. E. (2008). Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res, 20(4), 302–309. https://doi.org/10.1007/BF03324860
Nicklas, Barbara J., Iris Leng, Osvaldo Delbono, Dalane W. Kitzman, Anthony P. Marsh, W Gregory Hundley, Mary F. Lyles, Kenneth S. O’Rourke, Brian H. Annex, and William E. Kraus. “Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women.Aging Clin Exp Res 20, no. 4 (August 2008): 302–9. https://doi.org/10.1007/BF03324860.
Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, et al. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008 Aug;20(4):302–9.
Nicklas, Barbara J., et al. “Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women.Aging Clin Exp Res, vol. 20, no. 4, Aug. 2008, pp. 302–09. Pubmed, doi:10.1007/BF03324860.
Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O’Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008 Aug;20(4):302–309.
Journal cover image

Published In

Aging Clin Exp Res

DOI

ISSN

1594-0667

Publication Date

August 2008

Volume

20

Issue

4

Start / End Page

302 / 309

Location

Germany

Related Subject Headings

  • Quadriceps Muscle
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Female
  • Capillaries
  • Body Mass Index
  • Aged, 80 and over
  • Aged