Skip to main content
Journal cover image

The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation.

Publication ,  Journal Article
Chen, S; Ling, Z; Yin, Y; Li, C; Zhang, B; Zrenner, B; Krucoff, MW
Published in: J Interv Card Electrophysiol
August 2012

PURPOSE: The purpose of this study was to compare the efficacy of focused ultrasound circumferential pulmonary vein ablation (CPVa) and BOX ablation (BOXa) in an acute atrial fibrillation (AF) model. METHODS: Twenty mongrel dogs were divided into either CPVa or BOXa groups. CPV or BOX focused ultrasonic ablation was conducted in each group after successful establishment of the AF model. Before-and-after ablation left atrial effective refractory period (LAERP), AF inducibility, and induced AF lasting time were measured in both groups. RESULTS: The LAERP after AF model establishment was significantly shorter than that before establishment (102 ± 10 vs. 140 ± 10 ms, p < 0.01, in the CPVa group; 105 ± 8 vs. 139 ± 11 ms, p < 0.01, in the BOXa group). The AF inducibility after ablation was significantly lower than that before ablation in the two groups (98% vs. 28%, p < 0.01, in the CPVa group; 97% vs.14%, p < 0.01, in the BOXa group), and the induced AF lasting time after ablation was significantly shorter than that before ablation in both groups (233 ± 40 vs. 70 ± 29 s, p < 0.01, in the CPVa group; 240 ± 41 vs. 34 ± 22 s, p < 0.01, in the BOXa group). On intergroup comparison, AF inducibility and induced AF lasting time after ablation were significantly lower/shorter in the BOXa group than those in the CPVa group (14% vs. 28%, p = 0.021; 34 ± 22 vs. 70 ± 29 s, p = 0.048, respectively). CONCLUSIONS: In the experimental AF model, the epicardial focused ultrasound BOX ablation may be more effective to prevent the recurrence of AF compared with the CPV approach.

Duke Scholars

Published In

J Interv Card Electrophysiol

DOI

EISSN

1572-8595

Publication Date

August 2012

Volume

34

Issue

2

Start / End Page

153 / 159

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Secondary Prevention
  • Pulmonary Veins
  • High-Intensity Focused Ultrasound Ablation
  • Heart Conduction System
  • Dogs
  • Catheter Ablation
  • Cardiovascular System & Hematology
  • Atrial Fibrillation
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, S., Ling, Z., Yin, Y., Li, C., Zhang, B., Zrenner, B., & Krucoff, M. W. (2012). The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation. J Interv Card Electrophysiol, 34(2), 153–159. https://doi.org/10.1007/s10840-011-9659-9
Chen, Shaojie, Zhiyu Ling, Yuehui Yin, Chengzhi Li, Bo Zhang, Bernhard Zrenner, and Mitchell W. Krucoff. “The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation.J Interv Card Electrophysiol 34, no. 2 (August 2012): 153–59. https://doi.org/10.1007/s10840-011-9659-9.
Chen S, Ling Z, Yin Y, Li C, Zhang B, Zrenner B, et al. The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation. J Interv Card Electrophysiol. 2012 Aug;34(2):153–9.
Chen, Shaojie, et al. “The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation.J Interv Card Electrophysiol, vol. 34, no. 2, Aug. 2012, pp. 153–59. Pubmed, doi:10.1007/s10840-011-9659-9.
Chen S, Ling Z, Yin Y, Li C, Zhang B, Zrenner B, Krucoff MW. The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation--results from experimental acute atrial fibrillation. J Interv Card Electrophysiol. 2012 Aug;34(2):153–159.
Journal cover image

Published In

J Interv Card Electrophysiol

DOI

EISSN

1572-8595

Publication Date

August 2012

Volume

34

Issue

2

Start / End Page

153 / 159

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Secondary Prevention
  • Pulmonary Veins
  • High-Intensity Focused Ultrasound Ablation
  • Heart Conduction System
  • Dogs
  • Catheter Ablation
  • Cardiovascular System & Hematology
  • Atrial Fibrillation
  • Animals