Skip to main content
Journal cover image

In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study.

Publication ,  Journal Article
Waxman, S; Dixon, SR; L'Allier, P; Moses, JW; Petersen, JL; Cutlip, D; Tardif, J-C; Nesto, RW; Muller, JE; Hendricks, MJ; Sum, ST; Gardner, CM ...
Published in: JACC Cardiovasc Imaging
July 2009

OBJECTIVES: To determine whether catheter-based near-infrared spectroscopy (NIRS) signals obtained with a novel catheter-based system from coronaries of patients are similar to those from autopsy specimens and to assess initial safety of NIRS device. BACKGROUND: An intravascular NIRS system for detection of lipid core-containing plaques (LCP) has been validated in human coronary autopsy specimens. The SPECTACL (SPECTroscopic Assessment of Coronary Lipid) trial was a parallel first-in-human multicenter study designed to demonstrate the applicability of the LCP detection algorithm in living patients. METHODS: Intracoronary NIRS was performed in patients undergoing percutaneous coronary intervention. Acquired spectra were blindly compared with autopsy NIRS signals with multivariate statistics. To meet the end point of spectral similarity, at least two-thirds of the scans were required to have >80% of spectra similar to the autopsy spectra. RESULTS: A total of 106 patients were enrolled; there were no serious adverse events attributed to NIRS. Spectroscopic data could not be obtained in 17 (16%) patients due to technical limitations, leaving 89 patients for analysis. Spectra from 30 patients were unblinded to test the calibration of the LCP detection algorithm. Of the remaining 59 blinded cases, after excluding 11 due to inadequate data, spectral similarity was demonstrated in 40 of 48 spectrally adequate scans (83% success rate, 95% confidence interval: 70% to 93%, median spectral similarity/pullback: 96%, interquartile range 10%). The LCP was detected in 58% of 60 spectrally similar scans from both cohorts. CONCLUSIONS: This intravascular NIRS system safely obtained spectral data in patients that were similar to those from autopsy specimens. These results demonstrate the feasibility of invasive detection of coronary LCP with this novel system. (SPECTACL: SPECTroscopic Assessment of Coronary Lipid; NCT00330928).

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JACC Cardiovasc Imaging

DOI

EISSN

1876-7591

Publication Date

July 2009

Volume

2

Issue

7

Start / End Page

858 / 868

Location

United States

Related Subject Headings

  • United States
  • Spectroscopy, Near-Infrared
  • Reproducibility of Results
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • Female
  • Feasibility Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Waxman, S., Dixon, S. R., L’Allier, P., Moses, J. W., Petersen, J. L., Cutlip, D., … Krucoff, M. W. (2009). In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study. JACC Cardiovasc Imaging, 2(7), 858–868. https://doi.org/10.1016/j.jcmg.2009.05.001
Waxman, Sergio, Simon R. Dixon, Philippe L’Allier, Jeffrey W. Moses, John L. Petersen, Donald Cutlip, Jean-Claude Tardif, et al. “In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study.JACC Cardiovasc Imaging 2, no. 7 (July 2009): 858–68. https://doi.org/10.1016/j.jcmg.2009.05.001.
Waxman S, Dixon SR, L’Allier P, Moses JW, Petersen JL, Cutlip D, et al. In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study. JACC Cardiovasc Imaging. 2009 Jul;2(7):858–68.
Waxman, Sergio, et al. “In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study.JACC Cardiovasc Imaging, vol. 2, no. 7, July 2009, pp. 858–68. Pubmed, doi:10.1016/j.jcmg.2009.05.001.
Waxman S, Dixon SR, L’Allier P, Moses JW, Petersen JL, Cutlip D, Tardif J-C, Nesto RW, Muller JE, Hendricks MJ, Sum ST, Gardner CM, Goldstein JA, Stone GW, Krucoff MW. In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study. JACC Cardiovasc Imaging. 2009 Jul;2(7):858–868.
Journal cover image

Published In

JACC Cardiovasc Imaging

DOI

EISSN

1876-7591

Publication Date

July 2009

Volume

2

Issue

7

Start / End Page

858 / 868

Location

United States

Related Subject Headings

  • United States
  • Spectroscopy, Near-Infrared
  • Reproducibility of Results
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • Female
  • Feasibility Studies