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Coronary cyclic flow variations following primary angioplasty is associated with poor short-term prognosis.

Publication ,  Journal Article
Albertal, M; Cura, F; Krucoff, MW; Baeza, R; Garcia Escudero, A; Padilla, LT; Thierer, J; Fieg, S; Trivi, M; Belardi, JA; PREMIAR investigators,
Published in: Int J Cardiol
November 12, 2008

AIMS: Recent studies have shown that coronary cyclic flow variations (CCFV) is a platelet-related phenomenon that occurred following reperfusion. Although CCFV predicts acute complications following thrombolytic therapy, its impact following percutaneous coronary interventions (PCI) has not been evaluated yet. METHODS AND RESULTS: One hundred and thirty-one patients with ST-segment Elevation Myocardial Infarction (STEMI) who underwent PCI were included in the analysis. All patients have 24-hour ST-segment monitoring. The development of CCFV was defined as > or = 3 ST-segment transitions (> or =150 microV). We divided the population in two groups according to the presence (n=14, 10.6%) or absence (n=117) of CCFV. The relation between CCFV and 30-day major adverse cardiac events (MACE) was analyzed using a multivariate logistic regression model adjusting for age, sex, diabetes, smoking, anterior infarct, Killip class, and final TIMI flow grade. Clinical and angiographic characteristics were similar between the two groups. Higher 30-day mortality (21.4 vs. 3.8%, p=0.022) and MACE rates (42.9 vs. 10.7%, p=0.005) were seen in the CCFV group. Multivariate regression analysis revealed that patients with CCFV were at increased risk of 30-day MACE (adjusted RR 5.09; 95% CI 1.3-19.1; p=0.0016). CONCLUSION: The presence of CCFV altered primary PCI may provide an early indication of insufficient myocardial perfusion and impending catastrophic outcome.

Duke Scholars

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

November 12, 2008

Volume

130

Issue

2

Start / End Page

220 / 226

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Prospective Studies
  • Prognosis
  • Myocardial Reperfusion
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
 

Citation

APA
Chicago
ICMJE
MLA
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Albertal, M., Cura, F., Krucoff, M. W., Baeza, R., Garcia Escudero, A., Padilla, L. T., … PREMIAR investigators, . (2008). Coronary cyclic flow variations following primary angioplasty is associated with poor short-term prognosis. Int J Cardiol, 130(2), 220–226. https://doi.org/10.1016/j.ijcard.2007.08.085
Albertal, Mariano, Fernando Cura, Mitchell W. Krucoff, Ricardo Baeza, Alejandro Garcia Escudero, Lucio T. Padilla, Jorge Thierer, et al. “Coronary cyclic flow variations following primary angioplasty is associated with poor short-term prognosis.Int J Cardiol 130, no. 2 (November 12, 2008): 220–26. https://doi.org/10.1016/j.ijcard.2007.08.085.
Albertal M, Cura F, Krucoff MW, Baeza R, Garcia Escudero A, Padilla LT, et al. Coronary cyclic flow variations following primary angioplasty is associated with poor short-term prognosis. Int J Cardiol. 2008 Nov 12;130(2):220–6.
Albertal, Mariano, et al. “Coronary cyclic flow variations following primary angioplasty is associated with poor short-term prognosis.Int J Cardiol, vol. 130, no. 2, Nov. 2008, pp. 220–26. Pubmed, doi:10.1016/j.ijcard.2007.08.085.
Albertal M, Cura F, Krucoff MW, Baeza R, Garcia Escudero A, Padilla LT, Thierer J, Fieg S, Trivi M, Belardi JA, PREMIAR investigators. Coronary cyclic flow variations following primary angioplasty is associated with poor short-term prognosis. Int J Cardiol. 2008 Nov 12;130(2):220–226.
Journal cover image

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

November 12, 2008

Volume

130

Issue

2

Start / End Page

220 / 226

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Prospective Studies
  • Prognosis
  • Myocardial Reperfusion
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Heart Failure