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Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy.

Publication ,  Journal Article
Field, T; Diego, M; Hernandez-Reif, M; Dieter, JNI; Kumar, AM; Schanberg, S; Kuhn, C
Published in: J Dev Behav Pediatr
December 2008

OBJECTIVE: To determine if massage therapy increased serum insulin and insulin-like growth factor-1 (IGF-1) in preterm neonates. STUDY DESIGN: Forty-two preterm neonates who averaged 34.6 weeks (M = 29.5 wk gestational age; M birth weight = 1237 g) and were in the "grower" (step-down) nursery were randomly assigned to a massage therapy group (body stroking and passive limb movements for three, 15-minute periods per day for 5 days) or a control group that received the standard nursery care without massage therapy. On Days 1 and 5, the serum collected by clinical heelsticks was also assayed for insulin and IGF-1, and weight gain and kilocalories consumed were recorded daily. RESULTS: Despite similar formula intake, the massaged preterm neonates showed greater increases during the 5-day period in (1) weight gain; (2) serum levels of insulin; and (3) IGF-1. Increased weight gain was significantly correlated with insulin and IGF-1. DISCUSSION: Previous data suggested that preterm infant weight gain following massage therapy related to increased vagal activity, which suggests decreased stress and gastric motility, which may contribute to more efficient food absorption. The data from this study suggest for the first time that weight gain was also related to increased serum insulin and IGF-1 levels following massage therapy. CONCLUSION: Preterm infants who received massage therapy not only showed greater weight gain but also a greater increase in serum insulin and IGF-1 levels, suggesting that massage therapy might be prescribed for all growing neonates.

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Published In

J Dev Behav Pediatr

DOI

EISSN

1536-7312

Publication Date

December 2008

Volume

29

Issue

6

Start / End Page

463 / 466

Location

United States

Related Subject Headings

  • Weight Gain
  • Time Factors
  • Massage
  • Male
  • Insulin-Like Growth Factor I
  • Insulin
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
 

Citation

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Field, T., Diego, M., Hernandez-Reif, M., Dieter, J. N. I., Kumar, A. M., Schanberg, S., & Kuhn, C. (2008). Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy. J Dev Behav Pediatr, 29(6), 463–466. https://doi.org/10.1097/DBP.0b013e3181856d3b
Field, Tiffany, Miguel Diego, Maria Hernandez-Reif, John N. I. Dieter, Adarsh M. Kumar, Saul Schanberg, and Cynthia Kuhn. “Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy.J Dev Behav Pediatr 29, no. 6 (December 2008): 463–66. https://doi.org/10.1097/DBP.0b013e3181856d3b.
Field T, Diego M, Hernandez-Reif M, Dieter JNI, Kumar AM, Schanberg S, et al. Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy. J Dev Behav Pediatr. 2008 Dec;29(6):463–6.
Field, Tiffany, et al. “Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy.J Dev Behav Pediatr, vol. 29, no. 6, Dec. 2008, pp. 463–66. Pubmed, doi:10.1097/DBP.0b013e3181856d3b.
Field T, Diego M, Hernandez-Reif M, Dieter JNI, Kumar AM, Schanberg S, Kuhn C. Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy. J Dev Behav Pediatr. 2008 Dec;29(6):463–466.

Published In

J Dev Behav Pediatr

DOI

EISSN

1536-7312

Publication Date

December 2008

Volume

29

Issue

6

Start / End Page

463 / 466

Location

United States

Related Subject Headings

  • Weight Gain
  • Time Factors
  • Massage
  • Male
  • Insulin-Like Growth Factor I
  • Insulin
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans