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The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men.

Publication ,  Journal Article
Suarez, EC; Lewis, JG; Kuhn, C
Published in: Brain Behav Immun
December 2002

Aggression, hostility, and anger significantly predict morbidity and mortality from atherosclerotic cardiovascular disease (ACVD). ACVD is believed to be an inflammatory disease characterized by increased expression of a number of proinflammatory cytokines, such as tumor necrosis factor (TNF)-alpha. This study examined the relation of aggression, hostility, and anger to monocyte-associated TNF-alpha expression following lipopolysaccharide (LPS) stimulation. Participants were 62 healthy, non-smoking men (aged 18-45 years). Hostility, anger, verbal, and physical aggression were assessed using the Buss-Perry aggression questionnaire (BPAQ). LPS-stimulated TNF-alpha expression was determined using dual-color flow cytometry gating for CD14(+) cells. After controlling for age, race, education, and alcohol use, scores on the hostility (p=.013), physical aggression (p=.010), and verbal aggression (p=.034) subscales, and the total score (p=.007) on the BPAQ were positively associated with LPS-stimulated TNF-alpha expression. The results suggest that hostility and aggression are associated with an increased expression of TNF-alpha, a cytokine implicated in ACVD.

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Published In

Brain Behav Immun

DOI

ISSN

0889-1591

Publication Date

December 2002

Volume

16

Issue

6

Start / End Page

675 / 684

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Neurology & Neurosurgery
  • Neuroimmunomodulation
  • Monocytes
  • Middle Aged
  • Male
  • Lipopolysaccharides
  • Humans
  • Hostility
  • Arteriosclerosis
 

Citation

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Suarez, E. C., Lewis, J. G., & Kuhn, C. (2002). The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men. Brain Behav Immun, 16(6), 675–684. https://doi.org/10.1016/s0889-1591(02)00019-3
Suarez, Edward C., James G. Lewis, and Cynthia Kuhn. “The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men.Brain Behav Immun 16, no. 6 (December 2002): 675–84. https://doi.org/10.1016/s0889-1591(02)00019-3.
Suarez, Edward C., et al. “The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men.Brain Behav Immun, vol. 16, no. 6, Dec. 2002, pp. 675–84. Pubmed, doi:10.1016/s0889-1591(02)00019-3.
Journal cover image

Published In

Brain Behav Immun

DOI

ISSN

0889-1591

Publication Date

December 2002

Volume

16

Issue

6

Start / End Page

675 / 684

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Neurology & Neurosurgery
  • Neuroimmunomodulation
  • Monocytes
  • Middle Aged
  • Male
  • Lipopolysaccharides
  • Humans
  • Hostility
  • Arteriosclerosis