Skip to main content

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.

Publication ,  Journal Article
Butler, AA; Marks, DL; Fan, W; Kuhn, CM; Bartolome, M; Cone, RD
Published in: Nat Neurosci
June 2001

In response to moderately increased dietary fat content, melanocortin-4 receptor-null mutant (MC4R-/-) mice exhibit hyperphagia and accelerated weight gain compared to wild-type mice. An increased feed efficiency (weight gain/kcal consumed) argues that mechanisms in addition to hyperphagia are instrumental in causing weight gain. We report two specific defects in coordinating energy expenditure with food intake in MC4R-/- mice. Wild-type mice respond to an increase in the fat content of the diet by rapidly increasing diet-induced thermogenesis and by increasing physical activity, neither of which are observed in MC4R-/- mice. Leptin-deficient and MC3R-/- mice regulate metabolic rate similarly to wild-type mice in this protocol. Melanocortinergic pathways involving MC4-R-regulated neurons, which rapidly respond to signals not requiring changes in leptin, thus seem to be important in regulating metabolic and behavioral responses to dietary fat.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

June 2001

Volume

4

Issue

6

Start / End Page

605 / 611

Location

United States

Related Subject Headings

  • Weight Gain
  • Thermogenesis
  • Reference Values
  • Receptors, Corticotropin
  • Receptor, Melanocortin, Type 4
  • Receptor, Melanocortin, Type 3
  • Physical Exertion
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice, Inbred C57BL
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Butler, A. A., Marks, D. L., Fan, W., Kuhn, C. M., Bartolome, M., & Cone, R. D. (2001). Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci, 4(6), 605–611. https://doi.org/10.1038/88423
Butler, A. A., D. L. Marks, W. Fan, C. M. Kuhn, M. Bartolome, and R. D. Cone. “Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.Nat Neurosci 4, no. 6 (June 2001): 605–11. https://doi.org/10.1038/88423.
Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci. 2001 Jun;4(6):605–11.
Butler, A. A., et al. “Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.Nat Neurosci, vol. 4, no. 6, June 2001, pp. 605–11. Pubmed, doi:10.1038/88423.
Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci. 2001 Jun;4(6):605–611.

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

June 2001

Volume

4

Issue

6

Start / End Page

605 / 611

Location

United States

Related Subject Headings

  • Weight Gain
  • Thermogenesis
  • Reference Values
  • Receptors, Corticotropin
  • Receptor, Melanocortin, Type 4
  • Receptor, Melanocortin, Type 3
  • Physical Exertion
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice, Inbred C57BL