Sex, steroids, and stimulant sensitivity.
Publication
, Journal Article
Kuhn, CM; Walker, QD; Kaplan, KA; Li, ST
Published in: Ann N Y Acad Sci
June 2001
The current study investigated ovarian modulation of the locomotor response to cocaine in rats. Ovariectomy in females lowered the response to cocaine (10 mg/kg i.p.), whereas castration did not change that of males. The locomotor responses of prepubertal males and females to cocaine were similar. However, the postpubertal sex difference resulted from a fall in cocaine-stimulated locomotion in males rather than a rise in females. Neonatal testosterone treatment of female rat pups decreased the response to cocaine in adulthood. These findings suggest that both the activational and organizational effects of gonadal steroids contribute to the greater response of females to cocaine.
Duke Scholars
Published In
Ann N Y Acad Sci
DOI
ISSN
0077-8923
Publication Date
June 2001
Volume
937
Start / End Page
188 / 201
Location
United States
Related Subject Headings
- Testosterone
- Sex Factors
- Rats
- Ovariectomy
- Male
- Locomotion
- General Science & Technology
- Female
- Estradiol
- Dopamine Uptake Inhibitors
Citation
APA
Chicago
ICMJE
MLA
NLM
Kuhn, C. M., Walker, Q. D., Kaplan, K. A., & Li, S. T. (2001). Sex, steroids, and stimulant sensitivity. Ann N Y Acad Sci, 937, 188–201. https://doi.org/10.1111/j.1749-6632.2001.tb03565.x
Kuhn, C. M., Q. D. Walker, K. A. Kaplan, and S. T. Li. “Sex, steroids, and stimulant sensitivity.” Ann N Y Acad Sci 937 (June 2001): 188–201. https://doi.org/10.1111/j.1749-6632.2001.tb03565.x.
Kuhn CM, Walker QD, Kaplan KA, Li ST. Sex, steroids, and stimulant sensitivity. Ann N Y Acad Sci. 2001 Jun;937:188–201.
Kuhn, C. M., et al. “Sex, steroids, and stimulant sensitivity.” Ann N Y Acad Sci, vol. 937, June 2001, pp. 188–201. Pubmed, doi:10.1111/j.1749-6632.2001.tb03565.x.
Kuhn CM, Walker QD, Kaplan KA, Li ST. Sex, steroids, and stimulant sensitivity. Ann N Y Acad Sci. 2001 Jun;937:188–201.
Published In
Ann N Y Acad Sci
DOI
ISSN
0077-8923
Publication Date
June 2001
Volume
937
Start / End Page
188 / 201
Location
United States
Related Subject Headings
- Testosterone
- Sex Factors
- Rats
- Ovariectomy
- Male
- Locomotion
- General Science & Technology
- Female
- Estradiol
- Dopamine Uptake Inhibitors