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Sex, steroids, and stimulant sensitivity.

Publication ,  Journal Article
Kuhn, CM; Walker, QD; Kaplan, KA; Li, ST
Published in: Ann N Y Acad Sci
June 2001

The current study investigated ovarian modulation of the locomotor response to cocaine in rats. Ovariectomy in females lowered the response to cocaine (10 mg/kg i.p.), whereas castration did not change that of males. The locomotor responses of prepubertal males and females to cocaine were similar. However, the postpubertal sex difference resulted from a fall in cocaine-stimulated locomotion in males rather than a rise in females. Neonatal testosterone treatment of female rat pups decreased the response to cocaine in adulthood. These findings suggest that both the activational and organizational effects of gonadal steroids contribute to the greater response of females to cocaine.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

June 2001

Volume

937

Start / End Page

188 / 201

Location

United States

Related Subject Headings

  • Testosterone
  • Sex Factors
  • Rats
  • Ovariectomy
  • Male
  • Locomotion
  • General Science & Technology
  • Female
  • Estradiol
  • Dopamine Uptake Inhibitors
 

Citation

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MLA
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Kuhn, C. M., Walker, Q. D., Kaplan, K. A., & Li, S. T. (2001). Sex, steroids, and stimulant sensitivity. Ann N Y Acad Sci, 937, 188–201. https://doi.org/10.1111/j.1749-6632.2001.tb03565.x
Kuhn, C. M., Q. D. Walker, K. A. Kaplan, and S. T. Li. “Sex, steroids, and stimulant sensitivity.Ann N Y Acad Sci 937 (June 2001): 188–201. https://doi.org/10.1111/j.1749-6632.2001.tb03565.x.
Kuhn CM, Walker QD, Kaplan KA, Li ST. Sex, steroids, and stimulant sensitivity. Ann N Y Acad Sci. 2001 Jun;937:188–201.
Kuhn, C. M., et al. “Sex, steroids, and stimulant sensitivity.Ann N Y Acad Sci, vol. 937, June 2001, pp. 188–201. Pubmed, doi:10.1111/j.1749-6632.2001.tb03565.x.
Kuhn CM, Walker QD, Kaplan KA, Li ST. Sex, steroids, and stimulant sensitivity. Ann N Y Acad Sci. 2001 Jun;937:188–201.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

June 2001

Volume

937

Start / End Page

188 / 201

Location

United States

Related Subject Headings

  • Testosterone
  • Sex Factors
  • Rats
  • Ovariectomy
  • Male
  • Locomotion
  • General Science & Technology
  • Female
  • Estradiol
  • Dopamine Uptake Inhibitors