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Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.

Publication ,  Journal Article
King, GR; Joyner, C; Lee, T; Kuhn, C; Ellinwood, EH
Published in: Pharmacol Biochem Behav
September 1992

Rats were pretreated with 40 mg/kg/day cocaine for 14 days by either subcutaneous injections or osmotic minipumps. Rats were then withdrawn from the pretreatment regime for 1 or 7 days and given a 20-mg/kg IP cocaine challenge (day 1) or a 0-, 10-, 20-, or 40-mg/kg IP cocaine challenge (day 7). The results indicate that rats receiving intermittent, daily injections exhibited sensitization to the behavioral effects of a cocaine challenge on days 1 and 7 of withdrawal. In contrast, rats receiving continuous cocaine exhibited tolerance to the behavioral effects of a cocaine challenge on days 1 and 7 of withdrawal. The present results support and extend previous research that indicates that the route and temporal pattern of administration influences the effects of chronic cocaine. Furthermore, the present results indicate that the continuous infusion paradigm may represent an alternative animal model of some aspects of high-dose cocaine abuse, as compared to the typical procedure of single, or multiple, daily cocaine injections.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

September 1992

Volume

43

Issue

1

Start / End Page

243 / 248

Location

United States

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Rats, Sprague-Dawley
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Injections, Subcutaneous
  • Drug Implants
  • Dose-Response Relationship, Drug
  • Cocaine
  • Behavior, Animal
 

Citation

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King, G. R., Joyner, C., Lee, T., Kuhn, C., & Ellinwood, E. H. (1992). Intermittent and continuous cocaine administration: residual behavioral states during withdrawal. Pharmacol Biochem Behav, 43(1), 243–248. https://doi.org/10.1016/0091-3057(92)90664-2
King, G. R., C. Joyner, T. Lee, C. Kuhn, and E. H. Ellinwood. “Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.Pharmacol Biochem Behav 43, no. 1 (September 1992): 243–48. https://doi.org/10.1016/0091-3057(92)90664-2.
King GR, Joyner C, Lee T, Kuhn C, Ellinwood EH. Intermittent and continuous cocaine administration: residual behavioral states during withdrawal. Pharmacol Biochem Behav. 1992 Sep;43(1):243–8.
King, G. R., et al. “Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.Pharmacol Biochem Behav, vol. 43, no. 1, Sept. 1992, pp. 243–48. Pubmed, doi:10.1016/0091-3057(92)90664-2.
King GR, Joyner C, Lee T, Kuhn C, Ellinwood EH. Intermittent and continuous cocaine administration: residual behavioral states during withdrawal. Pharmacol Biochem Behav. 1992 Sep;43(1):243–248.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

September 1992

Volume

43

Issue

1

Start / End Page

243 / 248

Location

United States

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Rats, Sprague-Dawley
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Injections, Subcutaneous
  • Drug Implants
  • Dose-Response Relationship, Drug
  • Cocaine
  • Behavior, Animal