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D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats

Publication ,  Journal Article
Borowsky, B; Kuhn, CM
Published in: Neuropharmacology
1992

A stimulatory role for endogenous dopamine (DA) in the regulation of hypothalamo-pituitary-adrenal activity has previously been demonstrated. In the present study, the roles of D1 and D2 subtypes of DA receptors in the regulation of activity of the hypothalamo-pituitary-adrenal axis were investigated. The intraperitoneal administration of either the D1 agonist, SKF 383393 (1-phenyl-2,3,4,5 tetrahydro-(iH)-benzazepine-7,8diol HCl, 5-20 mg/kg) or the D2 agonist quinpirole (0.05-1 mg/kg) dose-dependently elevated both adrenocorticotropic hormone (ACTH) and corticosterone (CS) in serum. Similarly, administration of either SKF 38393 or quinpirole (1-100 μg) into the third ventricle dose-dependently elevated ACTH in serum. The response of ACTH to intraperitoneal SKF 38393 was blocked by pretreatment with the D1 antagonist SCH 23390 (1-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5 tetrahydro-1H-3-benzazepine, 0.25 mg/kg, i.p.) but not by the D2 antagonist sulpiride (50 mg/kg, i.p.). The response of ACTH to intraperitoneal injection of quinpirole was blocked by pretreatment with sulpiride and attenuated slightly by pretreatment with SCH 23390. Further, the co-administration of sub-maximum doses of SKF 38393 and quinpirole caused additive increases in ACTH in serum. These results suggest that both D1 and D2 subtypes of DA receptors contribute to the dopaminergic regulation of function of the hypothalamo-pituitary-adrenal axis and support a role for DA neurons in the hypothalamus in this response. Further, these findings suggest that the D1 and D2 receptors, mediating the response of the hypothalamopituitary-adrenal axis are not tightly coupled. The involvement of DA neurons in the hypothalamus, as well as the potent effect of quinpirole, suggest that D3 receptors may mediate this response. © 1984.

Duke Scholars

Published In

Neuropharmacology

ISSN

0028-3908

Publication Date

1992

Volume

31

Issue

7

Start / End Page

671 / 678

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1701 Psychology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1109 Neurosciences
 

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Borowsky, B., & Kuhn, C. M. (1992). D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. Neuropharmacology, 31(7), 671–678.
Borowsky, B., and C. M. Kuhn. “D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats.” Neuropharmacology 31, no. 7 (1992): 671–78.
Borowsky B, Kuhn CM. D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. Neuropharmacology. 1992;31(7):671–8.
Borowsky, B., and C. M. Kuhn. “D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats.” Neuropharmacology, vol. 31, no. 7, 1992, pp. 671–78.
Borowsky B, Kuhn CM. D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. Neuropharmacology. 1992;31(7):671–678.
Journal cover image

Published In

Neuropharmacology

ISSN

0028-3908

Publication Date

1992

Volume

31

Issue

7

Start / End Page

671 / 678

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 1701 Psychology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1109 Neurosciences