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Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders.

Publication ,  Journal Article
Nishita, JK; Ellinwood, EH; Rockwell, WJ; Kuhn, CM; Hoffman, GW; McCall, WV; Manepalli, JN
Published in: Biol Psychiatry
May 1989

We examined the response of plasma arginine vasopressin (pAVP) to intravenous 5% hypertonic saline in patients with anorexia nervosa (AN) and bulimia nervosa (BN). Patients did not differ from controls in their subjective response for the onset of thirst; however, only 5 patients (3 AN and 2 BN) showed pAVP levels that were within the normal range (0.5-11.0 pg/ml) for this test. With the exception of two eating disorder (ED) patients, all others showed some nonlinear irregularities in the pattern of their secretion of pAVP in response to the hypertonic saline infusion. Seven of the ED patients showed an irregular abnormally high pAVP secretion, and three patients showed abnormally low pAVP responses. Both of these pAVP secretion abnormalities occurred in underweight and weight-recovered AN patients, as well as in BN patients. The cause and pathophysiological consequences of these abnormalities remain unresolved.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

May 1989

Volume

26

Issue

1

Start / End Page

73 / 86

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • Sodium Chloride
  • Saline Solution, Hypertonic
  • Psychiatry
  • Hydrocortisone
  • Humans
  • Female
  • Bulimia
  • Body Weight
  • Arginine Vasopressin
 

Citation

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Nishita, J. K., Ellinwood, E. H., Rockwell, W. J., Kuhn, C. M., Hoffman, G. W., McCall, W. V., & Manepalli, J. N. (1989). Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders. Biol Psychiatry, 26(1), 73–86. https://doi.org/10.1016/0006-3223(89)90009-7
Nishita, J. K., E. H. Ellinwood, W. J. Rockwell, C. M. Kuhn, G. W. Hoffman, W. V. McCall, and J. N. Manepalli. “Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders.Biol Psychiatry 26, no. 1 (May 1989): 73–86. https://doi.org/10.1016/0006-3223(89)90009-7.
Nishita JK, Ellinwood EH, Rockwell WJ, Kuhn CM, Hoffman GW, McCall WV, et al. Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders. Biol Psychiatry. 1989 May;26(1):73–86.
Nishita, J. K., et al. “Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders.Biol Psychiatry, vol. 26, no. 1, May 1989, pp. 73–86. Pubmed, doi:10.1016/0006-3223(89)90009-7.
Nishita JK, Ellinwood EH, Rockwell WJ, Kuhn CM, Hoffman GW, McCall WV, Manepalli JN. Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders. Biol Psychiatry. 1989 May;26(1):73–86.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

May 1989

Volume

26

Issue

1

Start / End Page

73 / 86

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • Sodium Chloride
  • Saline Solution, Hypertonic
  • Psychiatry
  • Hydrocortisone
  • Humans
  • Female
  • Bulimia
  • Body Weight
  • Arginine Vasopressin