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Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.

Publication ,  Journal Article
Field, EA; Kuhn, CM
Published in: Life Sci
1989

In female neonatal rats, opiate receptor blockade markedly raises serum luteinizing hormone (LH) levels. The LH effect of acute treatment with opiate antagonists is apparently brief in older rats; however, age-related differences in antagonist pharmacokinetics may result in different LH response patterns. The duration of LH response to naloxone (NAL) and naltrexone (NTX) was examined in 5 day-old (d.o.) female rats and compared to the duration of analgesia blockade. The rise in serum LH following opiate receptor blockade in 5 d.o. rats was of similar duration to that previously observed in older animals and much briefer than blockade of analgesia. Furthermore, neonatal rats exhibited a delayed suppression of LH 6 hr following NAL, but not NTX, treatment. Stimulation and later suppression of LH were still observed after five repetitive NAL treatments at 6 hr intervals.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1989

Volume

44

Issue

26

Start / End Page

2025 / 2032

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Secretory Rate
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Pain
  • Naltrexone
  • Naloxone
  • Morphine
  • Luteinizing Hormone
 

Citation

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ICMJE
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Field, E. A., & Kuhn, C. M. (1989). Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats. Life Sci, 44(26), 2025–2032. https://doi.org/10.1016/0024-3205(89)90348-2
Field, E. A., and C. M. Kuhn. “Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.Life Sci 44, no. 26 (1989): 2025–32. https://doi.org/10.1016/0024-3205(89)90348-2.
Field, E. A., and C. M. Kuhn. “Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.Life Sci, vol. 44, no. 26, 1989, pp. 2025–32. Pubmed, doi:10.1016/0024-3205(89)90348-2.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1989

Volume

44

Issue

26

Start / End Page

2025 / 2032

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Secretory Rate
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Pain
  • Naltrexone
  • Naloxone
  • Morphine
  • Luteinizing Hormone