Skip to main content

Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.

Publication ,  Journal Article
Hassan, MN; Reches, A; Kuhn, C; Higgins, D; Fahn, S
Published in: Clin Neuropharmacol
1986

The occurrence of adverse extrapyramidal effects following metoclopramide (MCP) therapy has been well documented in humans. In rats, MCP produced catalepsy and inhibited apomorphine-induced stereotypy, locomotor activity, and rotational behavior. MCP also accelerated dopamine turnover, potently stimulated prolactin release, and, at high concentrations, inhibited [3H]spiperone binding to striatal membranes. These behavioral and biochemical effects induced by MCP were similar to those observed with haloperidol. We conclude that MCP possesses most of the pharmacological properties of neuroleptic agents.

Duke Scholars

Published In

Clin Neuropharmacol

DOI

ISSN

0362-5664

Publication Date

1986

Volume

9

Issue

1

Start / End Page

71 / 78

Location

United States

Related Subject Headings

  • Stereotyped Behavior
  • Spiperone
  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Neurology & Neurosurgery
  • Motor Activity
  • Metoclopramide
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hassan, M. N., Reches, A., Kuhn, C., Higgins, D., & Fahn, S. (1986). Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide. Clin Neuropharmacol, 9(1), 71–78. https://doi.org/10.1097/00002826-198602000-00008
Hassan, M. N., A. Reches, C. Kuhn, D. Higgins, and S. Fahn. “Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.Clin Neuropharmacol 9, no. 1 (1986): 71–78. https://doi.org/10.1097/00002826-198602000-00008.
Hassan MN, Reches A, Kuhn C, Higgins D, Fahn S. Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide. Clin Neuropharmacol. 1986;9(1):71–8.
Hassan, M. N., et al. “Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.Clin Neuropharmacol, vol. 9, no. 1, 1986, pp. 71–78. Pubmed, doi:10.1097/00002826-198602000-00008.
Hassan MN, Reches A, Kuhn C, Higgins D, Fahn S. Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide. Clin Neuropharmacol. 1986;9(1):71–78.

Published In

Clin Neuropharmacol

DOI

ISSN

0362-5664

Publication Date

1986

Volume

9

Issue

1

Start / End Page

71 / 78

Location

United States

Related Subject Headings

  • Stereotyped Behavior
  • Spiperone
  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Neurology & Neurosurgery
  • Motor Activity
  • Metoclopramide
  • Male