Skip to main content

Effect of chronic methadone administration on neuroendocrine function in developing rats.

Publication ,  Journal Article
Kuhn, CM; Bartolome, M
Published in: Dev Pharmacol Ther
1984

This paper reports the effects of chronic postnatal methadone administration on basal hormone levels and on the endocrine response to methadone. Chronic postnatal methadone administration delayed normal developmental increases in serum T4 (decrease on day 5), corticosterone (CS) (days 15 and 20) and growth hormone (GH) (day 25). In addition, marked tolerance to methadone effects on GH, CS, thyroid-stimulating hormone (TSH) and prolactin (PRL) secretion developed during chronic postnatal administration, and effects on PRL and TSH secretion persisted after drug withdrawal.

Duke Scholars

Published In

Dev Pharmacol Ther

DOI

ISSN

0379-8305

Publication Date

1984

Volume

7

Issue

6

Start / End Page

384 / 397

Location

Switzerland

Related Subject Headings

  • Time Factors
  • Thyroxine
  • Thyrotropin
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Neurosecretory Systems
  • Methadone
  • Male
  • Luteinizing Hormone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kuhn, C. M., & Bartolome, M. (1984). Effect of chronic methadone administration on neuroendocrine function in developing rats. Dev Pharmacol Ther, 7(6), 384–397. https://doi.org/10.1159/000457190
Kuhn, C. M., and M. Bartolome. “Effect of chronic methadone administration on neuroendocrine function in developing rats.Dev Pharmacol Ther 7, no. 6 (1984): 384–97. https://doi.org/10.1159/000457190.
Kuhn CM, Bartolome M. Effect of chronic methadone administration on neuroendocrine function in developing rats. Dev Pharmacol Ther. 1984;7(6):384–97.
Kuhn, C. M., and M. Bartolome. “Effect of chronic methadone administration on neuroendocrine function in developing rats.Dev Pharmacol Ther, vol. 7, no. 6, 1984, pp. 384–97. Pubmed, doi:10.1159/000457190.
Kuhn CM, Bartolome M. Effect of chronic methadone administration on neuroendocrine function in developing rats. Dev Pharmacol Ther. 1984;7(6):384–397.

Published In

Dev Pharmacol Ther

DOI

ISSN

0379-8305

Publication Date

1984

Volume

7

Issue

6

Start / End Page

384 / 397

Location

Switzerland

Related Subject Headings

  • Time Factors
  • Thyroxine
  • Thyrotropin
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Neurosecretory Systems
  • Methadone
  • Male
  • Luteinizing Hormone