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Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine.

Publication ,  Journal Article
McIntyre, IM; Kuhn, C; Demitriou, S; Fucek, FR; Stanley, M
Published in: Psychopharmacology (Berl)
1983

The effects of haloperidol, reserpine, and concomitant lithium were evaluated in biochemical, endocrine, and behavioral studies in the rat. Concomitant administration of a chronic regimen of haloperidol and lithium did not prevent the development of tolerance as noted by dopamine metabolites in the striatum or olfactory tuberculum. Nor did chronic lithium alter behavioral response in rats treated with reserpine and challenged with the dopamine agonist apomorphine. Additionally, prolactin release was increased by haloperidol, but was not altered by acute or chronic lithium treatment. These findings are discussed in the light of present knowledge of pre- and postsynaptic receptor changes and the effects of lithium.

Duke Scholars

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1983

Volume

81

Issue

2

Start / End Page

150 / 154

Location

Germany

Related Subject Headings

  • Reserpine
  • Rats, Inbred Strains
  • Rats
  • Psychiatry
  • Prolactin
  • Male
  • Lithium
  • Homovanillic Acid
  • Haloperidol
  • Drug Interactions
 

Citation

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McIntyre, I. M., Kuhn, C., Demitriou, S., Fucek, F. R., & Stanley, M. (1983). Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. Psychopharmacology (Berl), 81(2), 150–154. https://doi.org/10.1007/BF00429010
McIntyre, I. M., C. Kuhn, S. Demitriou, F. R. Fucek, and M. Stanley. “Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine.Psychopharmacology (Berl) 81, no. 2 (1983): 150–54. https://doi.org/10.1007/BF00429010.
McIntyre IM, Kuhn C, Demitriou S, Fucek FR, Stanley M. Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. Psychopharmacology (Berl). 1983;81(2):150–4.
McIntyre, I. M., et al. “Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine.Psychopharmacology (Berl), vol. 81, no. 2, 1983, pp. 150–54. Pubmed, doi:10.1007/BF00429010.
McIntyre IM, Kuhn C, Demitriou S, Fucek FR, Stanley M. Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. Psychopharmacology (Berl). 1983;81(2):150–154.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1983

Volume

81

Issue

2

Start / End Page

150 / 154

Location

Germany

Related Subject Headings

  • Reserpine
  • Rats, Inbred Strains
  • Rats
  • Psychiatry
  • Prolactin
  • Male
  • Lithium
  • Homovanillic Acid
  • Haloperidol
  • Drug Interactions