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Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.

Publication ,  Journal Article
Johnson, MD; Grignolo, A; Kuhn, CM; Schanberg, SM
Published in: Life Sci
July 11, 1983

Chronic continuous infusion of norepinephrine (NE) or epinephrine (Epi) subcutaneously in rats resulted in rapid elevation of systolic blood pressure (SBP) by 40 mm Hg. Pressure remained high for the duration of the infusion but rapidly returned to control levels after its termination. Pronounced hypertrophy of the thoracic aorta, abdominal aorta and heart was evident within 2 days of the initiation of NE infusion and a plateau was attained by 5 days of infusion. The activity of tissue ornithine decarboxylase (ODC), the rate limiting enzyme in polyamine biosynthesis, was elevated preceeding the onset of tissue hypertrophy, and returned to control levels coincidentally with the cessation of accelerated tissue growth. It is concluded that high blood pressure in this animal model of hypertension is dependent upon the continued presence of exogenous catecholamine, and that pronounced cardiovascular hypertrophy per se is not sufficient to maintain the hypertension. The elevation and decline of vascular ODC activity is consistent with reports that in other tissues an elevation of ODC activity is an obligatory early event in hypertrophy.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

July 11, 1983

Volume

33

Issue

2

Start / End Page

169 / 180

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Norepinephrine
  • Male
  • Injections, Subcutaneous
  • Hypertension
  • Epinephrine
 

Citation

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ICMJE
MLA
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Johnson, M. D., Grignolo, A., Kuhn, C. M., & Schanberg, S. M. (1983). Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats. Life Sci, 33(2), 169–180. https://doi.org/10.1016/0024-3205(83)90410-1
Johnson, M. D., A. Grignolo, C. M. Kuhn, and S. M. Schanberg. “Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.Life Sci 33, no. 2 (July 11, 1983): 169–80. https://doi.org/10.1016/0024-3205(83)90410-1.
Johnson MD, Grignolo A, Kuhn CM, Schanberg SM. Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats. Life Sci. 1983 Jul 11;33(2):169–80.
Johnson, M. D., et al. “Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.Life Sci, vol. 33, no. 2, July 1983, pp. 169–80. Pubmed, doi:10.1016/0024-3205(83)90410-1.
Johnson MD, Grignolo A, Kuhn CM, Schanberg SM. Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats. Life Sci. 1983 Jul 11;33(2):169–180.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

July 11, 1983

Volume

33

Issue

2

Start / End Page

169 / 180

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Norepinephrine
  • Male
  • Injections, Subcutaneous
  • Hypertension
  • Epinephrine