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Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans.

Publication ,  Journal Article
Coombs, CC; Rassenti, LZ; Falchi, L; Slager, SL; Strom, SS; Ferrajoli, A; Weinberg, JB; Kipps, TJ; Lanasa, MC
Published in: Blood
August 23, 2012

The incidence of chronic lymphocytic leukemia (CLL) is significantly lower in African Americans than whites, but overall survival is inferior. The biologic basis for these observations remains unexplored. We hypothesized that germline genetic predispositions differ between African Americans and whites with CLL and yield inferior clinical outcomes among African Americans. We examined a discovery cohort of 42 African American CLL patients ascertained at Duke University and found that the risk allele frequency of most single nucleotide polymorphisms known to confer risk of development for CLL is significantly lower among African Americans than whites. We then confirmed our results in a distinct cohort of 68 African American patients ascertained by the CLL Research Consortium. These results provide the first evidence supporting differential genetic risk for CLL between African Americans compared with whites. A fuller understanding of differential genetic risk may improve prognostication and therapeutic decision making for all CLL patients.

Duke Scholars

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

August 23, 2012

Volume

120

Issue

8

Start / End Page

1687 / 1690

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Male
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Incidence
  • Immunology
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Cohort Studies
 

Citation

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Coombs, C. C., Rassenti, L. Z., Falchi, L., Slager, S. L., Strom, S. S., Ferrajoli, A., … Lanasa, M. C. (2012). Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans. Blood, 120(8), 1687–1690. https://doi.org/10.1182/blood-2012-02-408799
Coombs, Catherine C., Laura Z. Rassenti, Lorenzo Falchi, Susan L. Slager, Sara S. Strom, Alessandra Ferrajoli, J Brice Weinberg, Thomas J. Kipps, and Mark C. Lanasa. “Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans.Blood 120, no. 8 (August 23, 2012): 1687–90. https://doi.org/10.1182/blood-2012-02-408799.
Coombs CC, Rassenti LZ, Falchi L, Slager SL, Strom SS, Ferrajoli A, et al. Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans. Blood. 2012 Aug 23;120(8):1687–90.
Coombs, Catherine C., et al. “Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans.Blood, vol. 120, no. 8, Aug. 2012, pp. 1687–90. Pubmed, doi:10.1182/blood-2012-02-408799.
Coombs CC, Rassenti LZ, Falchi L, Slager SL, Strom SS, Ferrajoli A, Weinberg JB, Kipps TJ, Lanasa MC. Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans. Blood. 2012 Aug 23;120(8):1687–1690.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

August 23, 2012

Volume

120

Issue

8

Start / End Page

1687 / 1690

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Male
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Incidence
  • Immunology
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Cohort Studies