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Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction

Publication ,  Journal Article
Rose, JE; Behm, FM; Westman, EC; Levin, ED; Stein, RM; Lane, JD; Ripka, GV
Published in: Experimental and Clinical Psychopharmacology
January 1, 1994
Published version (DOI)

Separate and combined effects of nicotine and the nicotinic antagonist mecamylamine were studied. Twelve smokers rated test cigarettes after administration of mecamylamine versus placebo capsules and nicotine versus nonnicotine preload. Smoking withdrawal symptoms, task performance, and cardiovascular activity were also measured. Mecamylamine attenuated smoking satisfaction, liking, and airway sensations. The nicotine preload similarly reduced the enjoyable aspects of subsequent test cigarettes, and this action of the preload was not prevented by mecamylamine. In contrast, mecamylamine blocked nicotine-related increases in heart rate and systolic blood pressure. Conversely, nicotine counteracted mecamylamine's effects on tapping speed and orthostatic blood pressure response. Although each drug offset potential side effects of the other, they acted in unison to attenuate smoking satisfaction and should be evaluated in combination for smoking cessation.

Duke Scholars

Jed Eugene Rose
Author Jed Eugene Rose Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
Edward Daniel Levin
Author Edward Daniel Levin Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
Eric Charles Westman
Author Eric Charles Westman Medicine, General Internal Medicine
Roy Mendel Stein
Author Roy Mendel Stein Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
James Dundas Lane
Author James Dundas Lane Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
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Published In

Experimental and Clinical Psychopharmacology

DOI

10.1037/1064-1297.2.4.328

ISSN

1064-1297

Publication Date

January 1, 1994

Volume

2

Issue

4

Start / End Page

328 / 344

Related Subject Headings

  • Substance Abuse
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 1701 Psychology
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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ICMJE
MLA
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Rose, J. E., Behm, F. M., Westman, E. C., Levin, E. D., Stein, R. M., Lane, J. D., & Ripka, G. V. (1994). Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction. Experimental and Clinical Psychopharmacology, 2(4), 328–344. https://doi.org/10.1037/1064-1297.2.4.328
Rose, J. E., F. M. Behm, E. C. Westman, E. D. Levin, R. M. Stein, J. D. Lane, and G. V. Ripka. “Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction.” Experimental and Clinical Psychopharmacology 2, no. 4 (January 1, 1994): 328–44. https://doi.org/10.1037/1064-1297.2.4.328.
Rose JE, Behm FM, Westman EC, Levin ED, Stein RM, Lane JD, et al. Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction. Experimental and Clinical Psychopharmacology. 1994 Jan 1;2(4):328–44.
Rose, J. E., et al. “Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction.” Experimental and Clinical Psychopharmacology, vol. 2, no. 4, Jan. 1994, pp. 328–44. Scopus, doi:10.1037/1064-1297.2.4.328.
Rose JE, Behm FM, Westman EC, Levin ED, Stein RM, Lane JD, Ripka GV. Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction. Experimental and Clinical Psychopharmacology. 1994 Jan 1;2(4):328–344.

Published In

Experimental and Clinical Psychopharmacology

DOI

10.1037/1064-1297.2.4.328

ISSN

1064-1297

Publication Date

January 1, 1994

Volume

2

Issue

4

Start / End Page

328 / 344

Related Subject Headings

  • Substance Abuse
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
  • 1701 Psychology
  • 1115 Pharmacology and Pharmaceutical Sciences