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Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.

Publication ,  Journal Article
el-Asrar, AM; Maimone, D; Morse, PH; Lascola, C; Reder, AT
Published in: Br J Ophthalmol
August 1991

Cultured rat retinal astrocytes were tested by indirect immunofluorescence staining for their ability to express class I and II major histocompatibility complex (MHC) antigens under basal culture conditions and after three days of stimulation with two recombinant cytokines, rat interferon-gamma (IFN-gamma) and human tumour necrosis factor alpha (TNF alpha). Under basal culture conditions low levels of class I antigens were detected on a small percentage of cells, but there was no visible class II. IFN-gamma and TNF alpha stimulation enhanced class I expression. TNF alpha had no effect on class II expression, whereas IFN-gamma induced the expression of class II in a dose dependent manner. These findings suggest that retinal astrocytes might play a part in immunological events occurring in the retina.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

August 1991

Volume

75

Issue

8

Start / End Page

473 / 475

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Stimulation, Chemical
  • Recombinant Proteins
  • Rats
  • Ophthalmology & Optometry
  • Interferon-gamma
  • Histocompatibility Antigens Class II
  • Histocompatibility Antigens Class I
  • Dose-Response Relationship, Drug
  • Cells, Cultured
 

Citation

APA
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MLA
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el-Asrar, A. M., Maimone, D., Morse, P. H., Lascola, C., & Reder, A. T. (1991). Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes. Br J Ophthalmol, 75(8), 473–475. https://doi.org/10.1136/bjo.75.8.473
Asrar, A. M. el-, D. Maimone, P. H. Morse, C. Lascola, and A. T. Reder. “Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.Br J Ophthalmol 75, no. 8 (August 1991): 473–75. https://doi.org/10.1136/bjo.75.8.473.
el-Asrar AM, Maimone D, Morse PH, Lascola C, Reder AT. Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes. Br J Ophthalmol. 1991 Aug;75(8):473–5.
el-Asrar, A. M., et al. “Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.Br J Ophthalmol, vol. 75, no. 8, Aug. 1991, pp. 473–75. Pubmed, doi:10.1136/bjo.75.8.473.
el-Asrar AM, Maimone D, Morse PH, Lascola C, Reder AT. Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes. Br J Ophthalmol. 1991 Aug;75(8):473–475.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

August 1991

Volume

75

Issue

8

Start / End Page

473 / 475

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Stimulation, Chemical
  • Recombinant Proteins
  • Rats
  • Ophthalmology & Optometry
  • Interferon-gamma
  • Histocompatibility Antigens Class II
  • Histocompatibility Antigens Class I
  • Dose-Response Relationship, Drug
  • Cells, Cultured