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Limiting lumens: a new role for Cdc42.

Publication ,  Journal Article
Lechler, T
Published in: J Cell Biol
November 17, 2008

The formation of a single lumen is a necessary step in the formation of biological tubes. Different tissues have developed diverse ways to form their lumens. In this issue, Jaffe et al. (Jaffe, A.B., N. Kaji, J. Durgan, and A. Hall. 2008. J. Cell Biol. 183:625-633) report the development of an in vitro system for studying lumen formation that is driven by fluid transport, recapitulating intestinal lumen formation. Effective ion and fluid transport requires both cell polarity and proper tissue organization. Surprisingly, polarization of cells in this three-dimensional system does not require Cdc42. Instead, Cdc42 prevents formation of multiple lumens by orienting cell divisions and directing apical membrane biogenesis.

Duke Scholars

Published In

J Cell Biol

DOI

EISSN

1540-8140

Publication Date

November 17, 2008

Volume

183

Issue

4

Start / End Page

575 / 577

Location

United States

Related Subject Headings

  • cdc42 GTP-Binding Protein
  • Spindle Apparatus
  • Humans
  • Epithelial Cells
  • Developmental Biology
  • Cell Polarity
  • Cell Division
  • Caco-2 Cells
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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MLA
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Lechler, T. (2008). Limiting lumens: a new role for Cdc42. J Cell Biol, 183(4), 575–577. https://doi.org/10.1083/jcb.200809174
Lechler, Terry. “Limiting lumens: a new role for Cdc42.J Cell Biol 183, no. 4 (November 17, 2008): 575–77. https://doi.org/10.1083/jcb.200809174.
Lechler T. Limiting lumens: a new role for Cdc42. J Cell Biol. 2008 Nov 17;183(4):575–7.
Lechler, Terry. “Limiting lumens: a new role for Cdc42.J Cell Biol, vol. 183, no. 4, Nov. 2008, pp. 575–77. Pubmed, doi:10.1083/jcb.200809174.
Lechler T. Limiting lumens: a new role for Cdc42. J Cell Biol. 2008 Nov 17;183(4):575–577.

Published In

J Cell Biol

DOI

EISSN

1540-8140

Publication Date

November 17, 2008

Volume

183

Issue

4

Start / End Page

575 / 577

Location

United States

Related Subject Headings

  • cdc42 GTP-Binding Protein
  • Spindle Apparatus
  • Humans
  • Epithelial Cells
  • Developmental Biology
  • Cell Polarity
  • Cell Division
  • Caco-2 Cells
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences