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Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction.

Publication ,  Journal Article
Sweeney, MO; Hellkamp, AS; Lee, KL; Lamas, GA; Mode Selection Trial (MOST) Investigators,
Published in: Circulation
May 17, 2005

BACKGROUND: Prolonged QRS duration (QRSd) is an important prognostic indicator for death and heart failure hospitalization in patients with systolic heart failure. The relationship of baseline QRSd to death and heart failure hospitalization in patients with sinus node dysfunction who require pacemaker therapy is unknown. METHODS AND RESULTS: Baseline QRSd from 12-lead ECGs before pacemaker implantation were analyzed in the Mode Selection Trial (MOST), a 6-year, 2010-patient randomized trial of dual-chamber versus ventricular pacing in sinus node dysfunction. Baseline QRSd was > or =120 ms in 23.4% of patients and was associated with older age, lower ejection fraction, cardiomyopathy, and prior heart failure. Adjusted Cox models demonstrated baseline QRSd > or =120 ms was a strong independent predictor of death (hazard ratio [95% CI] 1.35 [1.07, 1.70], P=0.010) but not heart failure hospitalization. The risk of death increased with increased QRSd from 60 to 120 ms (P=0.002 and hazard ratio [95% CI] 1.14 [1.05, 1.23] for 10-ms increase in this range) after adjustment for other death predictors. CONCLUSIONS: Baseline QRSd > or =120 ms was associated with increased risk of death during pacemaker therapy for sinus node dysfunction.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

May 17, 2005

Volume

111

Issue

19

Start / End Page

2418 / 2423

Location

United States

Related Subject Headings

  • Sinoatrial Node
  • Prognosis
  • Pacemaker, Artificial
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
  • Female
  • Electrophysiology
  • Death, Sudden, Cardiac
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sweeney, M. O., Hellkamp, A. S., Lee, K. L., Lamas, G. A., & Mode Selection Trial (MOST) Investigators, . (2005). Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation, 111(19), 2418–2423. https://doi.org/10.1161/01.CIR.0000165061.23825.A2
Sweeney, Michael O., Anne S. Hellkamp, Kerry L. Lee, Gervasio A. Lamas, and Gervasio A. Mode Selection Trial (MOST) Investigators. “Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction.Circulation 111, no. 19 (May 17, 2005): 2418–23. https://doi.org/10.1161/01.CIR.0000165061.23825.A2.
Sweeney MO, Hellkamp AS, Lee KL, Lamas GA, Mode Selection Trial (MOST) Investigators. Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2005 May 17;111(19):2418–23.
Sweeney, Michael O., et al. “Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction.Circulation, vol. 111, no. 19, May 2005, pp. 2418–23. Pubmed, doi:10.1161/01.CIR.0000165061.23825.A2.
Sweeney MO, Hellkamp AS, Lee KL, Lamas GA, Mode Selection Trial (MOST) Investigators. Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2005 May 17;111(19):2418–2423.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

May 17, 2005

Volume

111

Issue

19

Start / End Page

2418 / 2423

Location

United States

Related Subject Headings

  • Sinoatrial Node
  • Prognosis
  • Pacemaker, Artificial
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
  • Female
  • Electrophysiology
  • Death, Sudden, Cardiac