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Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT).

Publication ,  Journal Article
Ellison, KE; Hafley, GE; Hickey, K; Kellen, J; Coromilas, J; Stein, KM; Lee, KL; Buxton, AE; Multicenter UnSustained Tachycardia Trial Investigators,
Published in: Circulation
November 19, 2002

BACKGROUND: Beta-blockers are known to reduce total mortality and sudden death in survivors of recent myocardial infarction. The effects of these agents in patients at high risk for sudden death with remote infarction are not clear. METHODS AND RESULTS: We analyzed the effect of beta-blockers on outcomes in 2096 patients with coronary artery disease, ejection fraction < or =40%, and spontaneous nonsustained ventricular tachycardia enrolled in the Multicenter UnSustained Tachycardia Trial (MUSTT). Forty-five percent of 702 patients with inducible sustained ventricular tachyarrhythmia and 35% of 1394 patients without inducible tachycardia were discharged from hospital receiving beta-blockers. Patients treated with beta-blockers were younger and had higher ejection fractions, higher rates of recent angina, and more recent infarction. beta-Blockers were associated with decreased total mortality for the entire study population (5-year mortality 50% with beta-blockers versus 66% without beta-blockers; adjusted P=0.0001). The mortality benefit associated with beta-blockers was present in patients with and without inducible tachycardia, except those treated with implantable defibrillators. There was no significant effect of beta-blocker therapy on the rate of arrhythmic death or cardiac arrest (adjusted P=0.2344). CONCLUSIONS: beta-Blocking agents have beneficial effects on survival of patients having characteristics of those enrolled in the MUSTT trial. These effects do not appear to be due to a specific antiarrhythmic effect of beta-blockers. The beneficial effects of beta-blockers were demonstrable in all patients except those treated with implantable defibrillators.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 19, 2002

Volume

106

Issue

21

Start / End Page

2694 / 2699

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Tachycardia, Ventricular
  • Survival Rate
  • Stroke Volume
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
 

Citation

APA
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Ellison, K. E., Hafley, G. E., Hickey, K., Kellen, J., Coromilas, J., Stein, K. M., … Multicenter UnSustained Tachycardia Trial Investigators, . (2002). Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). Circulation, 106(21), 2694–2699. https://doi.org/10.1161/01.cir.0000038499.22687.39
Ellison, Kristin E., Gail E. Hafley, Kathleen Hickey, Joyce Kellen, James Coromilas, Kenneth M. Stein, Kerry L. Lee, Alfred E. Buxton, and Alfred E. Multicenter UnSustained Tachycardia Trial Investigators. “Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT).Circulation 106, no. 21 (November 19, 2002): 2694–99. https://doi.org/10.1161/01.cir.0000038499.22687.39.
Ellison KE, Hafley GE, Hickey K, Kellen J, Coromilas J, Stein KM, et al. Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). Circulation. 2002 Nov 19;106(21):2694–9.
Ellison, Kristin E., et al. “Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT).Circulation, vol. 106, no. 21, Nov. 2002, pp. 2694–99. Pubmed, doi:10.1161/01.cir.0000038499.22687.39.
Ellison KE, Hafley GE, Hickey K, Kellen J, Coromilas J, Stein KM, Lee KL, Buxton AE, Multicenter UnSustained Tachycardia Trial Investigators. Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). Circulation. 2002 Nov 19;106(21):2694–2699.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 19, 2002

Volume

106

Issue

21

Start / End Page

2694 / 2699

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Tachycardia, Ventricular
  • Survival Rate
  • Stroke Volume
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies