Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.
Publication
, Journal Article
Kovacs, JJ; Hara, MR; Davenport, CL; Kim, J; Lefkowitz, RJ
Published in: Dev Cell
October 2009
Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors--including those relevant to the Hedgehog, Wnt, Notch, and TGFbeta pathways--and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds.
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Published In
Dev Cell
DOI
EISSN
1878-1551
Publication Date
October 2009
Volume
17
Issue
4
Start / End Page
443 / 458
Location
United States
Related Subject Headings
- beta-Arrestins
- Signal Transduction
- Humans
- Gene Expression Regulation, Developmental
- Developmental Biology
- Arrestins
- Animals
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Kovacs, J. J., Hara, M. R., Davenport, C. L., Kim, J., & Lefkowitz, R. J. (2009). Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell, 17(4), 443–458. https://doi.org/10.1016/j.devcel.2009.09.011
Kovacs, Jeffrey J., Makoto R. Hara, Chandra L. Davenport, Jihee Kim, and Robert J. Lefkowitz. “Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.” Dev Cell 17, no. 4 (October 2009): 443–58. https://doi.org/10.1016/j.devcel.2009.09.011.
Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell. 2009 Oct;17(4):443–58.
Kovacs, Jeffrey J., et al. “Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.” Dev Cell, vol. 17, no. 4, Oct. 2009, pp. 443–58. Pubmed, doi:10.1016/j.devcel.2009.09.011.
Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell. 2009 Oct;17(4):443–458.
Published In
Dev Cell
DOI
EISSN
1878-1551
Publication Date
October 2009
Volume
17
Issue
4
Start / End Page
443 / 458
Location
United States
Related Subject Headings
- beta-Arrestins
- Signal Transduction
- Humans
- Gene Expression Regulation, Developmental
- Developmental Biology
- Arrestins
- Animals
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences