Skip to main content

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.

Publication ,  Journal Article
Lin, FT; Daaka, Y; Lefkowitz, RJ
Published in: J Biol Chem
November 27, 1998

beta-Arrestins mediate agonist-dependent desensitization of G protein-coupled receptors and target the receptors to clathrin-coated pits for internalization. Here we report an expanded role of beta-arrestins in promoting clathrin-mediated endocytosis of a tyrosine kinase growth factor receptor, i.e. the insulin-like growth factor I (IGF-1) receptor. beta-Arrestins bind to the ligand-occupied IGF-1 receptors, promote their endocytosis, and enhance IGF-1-dependent mitogen-activated protein kinase phosphorylation and DNA synthesis. Our results suggest a role for beta-arrestins in regulating mitogenic signaling and clathrin-mediated endocytosis of receptors not classically coupled to G proteins.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

November 27, 1998

Volume

273

Issue

48

Start / End Page

31640 / 31643

Location

United States

Related Subject Headings

  • beta-Arrestins
  • Transfection
  • Signal Transduction
  • Recombinant Proteins
  • Receptor, IGF Type 1
  • Phosphorylation
  • Humans
  • Endocytosis
  • DNA
  • Clathrin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lin, F. T., Daaka, Y., & Lefkowitz, R. J. (1998). beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem, 273(48), 31640–31643. https://doi.org/10.1074/jbc.273.48.31640
Lin, F. T., Y. Daaka, and R. J. Lefkowitz. “beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.J Biol Chem 273, no. 48 (November 27, 1998): 31640–43. https://doi.org/10.1074/jbc.273.48.31640.
Lin, F. T., et al. “beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.J Biol Chem, vol. 273, no. 48, Nov. 1998, pp. 31640–43. Pubmed, doi:10.1074/jbc.273.48.31640.

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

November 27, 1998

Volume

273

Issue

48

Start / End Page

31640 / 31643

Location

United States

Related Subject Headings

  • beta-Arrestins
  • Transfection
  • Signal Transduction
  • Recombinant Proteins
  • Receptor, IGF Type 1
  • Phosphorylation
  • Humans
  • Endocytosis
  • DNA
  • Clathrin