Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
Publication
, Journal Article
Luttrell, LM; Daaka, Y; Lefkowitz, RJ
Published in: Curr Opin Cell Biol
April 1999
Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.
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Published In
Curr Opin Cell Biol
DOI
ISSN
0955-0674
Publication Date
April 1999
Volume
11
Issue
2
Start / End Page
177 / 183
Location
England
Related Subject Headings
- src-Family Kinases
- beta-Arrestins
- Signal Transduction
- Receptors, Cell Surface
- Protein-Tyrosine Kinases
- Protein Processing, Post-Translational
- Models, Biological
- GTP-Binding Proteins
- Enzyme Activation
- Endocytosis
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Luttrell, L. M., Daaka, Y., & Lefkowitz, R. J. (1999). Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol, 11(2), 177–183. https://doi.org/10.1016/s0955-0674(99)80023-4
Luttrell, L. M., Y. Daaka, and R. J. Lefkowitz. “Regulation of tyrosine kinase cascades by G-protein-coupled receptors.” Curr Opin Cell Biol 11, no. 2 (April 1999): 177–83. https://doi.org/10.1016/s0955-0674(99)80023-4.
Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol. 1999 Apr;11(2):177–83.
Luttrell, L. M., et al. “Regulation of tyrosine kinase cascades by G-protein-coupled receptors.” Curr Opin Cell Biol, vol. 11, no. 2, Apr. 1999, pp. 177–83. Pubmed, doi:10.1016/s0955-0674(99)80023-4.
Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol. 1999 Apr;11(2):177–183.
Published In
Curr Opin Cell Biol
DOI
ISSN
0955-0674
Publication Date
April 1999
Volume
11
Issue
2
Start / End Page
177 / 183
Location
England
Related Subject Headings
- src-Family Kinases
- beta-Arrestins
- Signal Transduction
- Receptors, Cell Surface
- Protein-Tyrosine Kinases
- Protein Processing, Post-Translational
- Models, Biological
- GTP-Binding Proteins
- Enzyme Activation
- Endocytosis