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Biochemical mechanisms of β-adrenergic receptor regulation

Publication ,  Journal Article
Sibley, DR; Lefkowitz, RJ
Published in: ISI Atlas of Science: Pharmacology
January 1, 1988

β-Adrenergic receptors for catecholamines, which stimulate adenylate cyclase, are prototypes of a large gene family of receptors which interact with guanine nucleotide regulatory proteins. The function of such receptors is dynamically regulated so that stimulation by agonists is followed by desensitization. An important mechanism for such regulation appears to be covalent modification of the receptors by phosphorylation catalyzed by a variety of protein kinases.

Duke Scholars

Published In

ISI Atlas of Science: Pharmacology

ISSN

0890-9083

Publication Date

January 1, 1988

Volume

2

Issue

1

Start / End Page

66 / 70
 

Citation

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MLA
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Sibley, D. R., & Lefkowitz, R. J. (1988). Biochemical mechanisms of β-adrenergic receptor regulation. ISI Atlas of Science: Pharmacology, 2(1), 66–70.
Sibley, D. R., and R. J. Lefkowitz. “Biochemical mechanisms of β-adrenergic receptor regulation.” ISI Atlas of Science: Pharmacology 2, no. 1 (January 1, 1988): 66–70.
Sibley DR, Lefkowitz RJ. Biochemical mechanisms of β-adrenergic receptor regulation. ISI Atlas of Science: Pharmacology. 1988 Jan 1;2(1):66–70.
Sibley, D. R., and R. J. Lefkowitz. “Biochemical mechanisms of β-adrenergic receptor regulation.” ISI Atlas of Science: Pharmacology, vol. 2, no. 1, Jan. 1988, pp. 66–70.
Sibley DR, Lefkowitz RJ. Biochemical mechanisms of β-adrenergic receptor regulation. ISI Atlas of Science: Pharmacology. 1988 Jan 1;2(1):66–70.

Published In

ISI Atlas of Science: Pharmacology

ISSN

0890-9083

Publication Date

January 1, 1988

Volume

2

Issue

1

Start / End Page

66 / 70