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Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications.

Publication ,  Journal Article
Lefkowitz, RJ
Published in: Ann Intern Med
September 1979

Recently developed radioligand binding techniques permit direct investigation of the alpha- and beta-adrenergic receptors for catecholamines in a wide variety of tissues. These techniques allow the receptors to be quantitated, characterized, and studied under varying conditions of physiologic and pathophysiologic interest. They are providing fresh insights into the mechanisms by which endogenous catecholamines and other hormones regulate the properties of the adrenergic receptors and, in turn, control tissue sensitivity to catecholamine action.

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Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

September 1979

Volume

91

Issue

3

Start / End Page

450 / 458

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Radioligand Assay
  • Humans
  • Hormones
  • General & Internal Medicine
  • Catecholamines
  • Adrenergic beta-Antagonists
  • Adrenergic beta-Agonists
 

Citation

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Lefkowitz, R. J. (1979). Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications. Ann Intern Med, 91(3), 450–458. https://doi.org/10.7326/0003-4819-91-3-450
Lefkowitz, R. J. “Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications.Ann Intern Med 91, no. 3 (September 1979): 450–58. https://doi.org/10.7326/0003-4819-91-3-450.
Lefkowitz, R. J. “Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications.Ann Intern Med, vol. 91, no. 3, Sept. 1979, pp. 450–58. Pubmed, doi:10.7326/0003-4819-91-3-450.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

September 1979

Volume

91

Issue

3

Start / End Page

450 / 458

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Radioligand Assay
  • Humans
  • Hormones
  • General & Internal Medicine
  • Catecholamines
  • Adrenergic beta-Antagonists
  • Adrenergic beta-Agonists