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Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone.

Publication ,  Journal Article
Williams, LT; Lefkowitz, RJ
Published in: J Clin Invest
October 1977

The effects of estrogen and progesterone on uterine alpha-adrenergic receptors were investigated by direct receptor-binding studies. Immature female rabbits were primed with estrogen by intramuscular injections for 4 days. Other rabbits were primed with progesterone by injections of estrogen for 4 days followed by injections of progesterone for 4 days. The alpha adrenergic antagonist, [3H]dihydroergocryptine, was used to directly assess the number and affinity of alpha adrenergic receptors in membranes derived from estrogen-and progesterone-primed uteri. Membranes from estrogen-primed uteri contained 257 +/- 52 fmol of [3H]dihydroergocryptine-binding sites per mg protein whereas membranes from progesterone-primed uteri contained 83 +/- 11 fmol of of binding sites per mg protein. This reduction of alpha adrenergic receptor-binding sites by progesterone was statistically significant (P less than 0.02). In contrast, no significant difference in the binding site affinity was observed between the estrogen- and progesterone-primed groups. The progesterone-induced decrease in the number of uterine alpha adrenergic receptors provides a potential explanation for the reduced alpha adrenergic contractile response to epinephrine in the progesterone-primed myometrium.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

October 1977

Volume

60

Issue

4

Start / End Page

815 / 818

Location

United States

Related Subject Headings

  • Uterus
  • Uterine Contraction
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Rabbits
  • Progesterone
  • Myometrium
  • Kinetics
  • Immunology
  • Female
 

Citation

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Williams, L. T., & Lefkowitz, R. J. (1977). Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. J Clin Invest, 60(4), 815–818. https://doi.org/10.1172/JCI108835
Williams, L. T., and R. J. Lefkowitz. “Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone.J Clin Invest 60, no. 4 (October 1977): 815–18. https://doi.org/10.1172/JCI108835.
Williams LT, Lefkowitz RJ. Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. J Clin Invest. 1977 Oct;60(4):815–8.
Williams, L. T., and R. J. Lefkowitz. “Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone.J Clin Invest, vol. 60, no. 4, Oct. 1977, pp. 815–18. Pubmed, doi:10.1172/JCI108835.
Williams LT, Lefkowitz RJ. Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. J Clin Invest. 1977 Oct;60(4):815–818.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

October 1977

Volume

60

Issue

4

Start / End Page

815 / 818

Location

United States

Related Subject Headings

  • Uterus
  • Uterine Contraction
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Rabbits
  • Progesterone
  • Myometrium
  • Kinetics
  • Immunology
  • Female