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Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.

Publication ,  Journal Article
Yen, J; Donerly, S; Levin, ED; Linney, EA
Published in: Neurotoxicol Teratol
2011

Zebrafish are increasingly used for developmental neurotoxicity testing because early embryonic events are easy to visualize, exposures are done without affecting the mother and the rapid development of zebrafish allows for high throughput testing. We used zebrafish to examine how exposures to three different organophosphorus pesticides (chlorpyrifos, diazinon and parathion) over the first five days of embryonic and larval development of zebrafish affected their survival, acetylcholinesterase (AChE) activity and behavior. We show that at non-lethal, equimolar concentrations, chlorpyrifos (CPF) is more effective at equimolar concentrations than diazinon (DZN) and parathion (PA) in producing AChE inhibition. As concentrations of DZN and PA are raised, lethality occurs before they can produce the degree of AChE inhibition observed with CPF at 300 nM. Because of its availability outside the mother at the time of fertilization, zebrafish provides a complementary model for studying the neurotoxicity of very early developmental exposures.

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Published In

Neurotoxicol Teratol

DOI

EISSN

1872-9738

Publication Date

2011

Volume

33

Issue

6

Start / End Page

735 / 741

Location

United States

Related Subject Headings

  • Zebrafish
  • Toxicology
  • Structure-Activity Relationship
  • Parathion
  • Neurotoxicity Syndromes
  • Larva
  • Embryonic Development
  • Embryo, Nonmammalian
  • Dose-Response Relationship, Drug
  • Disease Models, Animal
 

Citation

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Yen, J., Donerly, S., Levin, E. D., & Linney, E. A. (2011). Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol, 33(6), 735–741. https://doi.org/10.1016/j.ntt.2011.10.004
Yen, Jerry, Sue Donerly, Edward D. Levin, and Elwood A. Linney. “Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.Neurotoxicol Teratol 33, no. 6 (2011): 735–41. https://doi.org/10.1016/j.ntt.2011.10.004.
Yen J, Donerly S, Levin ED, Linney EA. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol. 2011;33(6):735–41.
Yen, Jerry, et al. “Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.Neurotoxicol Teratol, vol. 33, no. 6, 2011, pp. 735–41. Pubmed, doi:10.1016/j.ntt.2011.10.004.
Yen J, Donerly S, Levin ED, Linney EA. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol. 2011;33(6):735–741.
Journal cover image

Published In

Neurotoxicol Teratol

DOI

EISSN

1872-9738

Publication Date

2011

Volume

33

Issue

6

Start / End Page

735 / 741

Location

United States

Related Subject Headings

  • Zebrafish
  • Toxicology
  • Structure-Activity Relationship
  • Parathion
  • Neurotoxicity Syndromes
  • Larva
  • Embryonic Development
  • Embryo, Nonmammalian
  • Dose-Response Relationship, Drug
  • Disease Models, Animal