Distinct CD4+ helper T cells involved in primary and secondary responses to infection.
Helper T cells are critical for protective immunity, CD8(+) T-cell memory, and CD4(+) recall responses, but whether the same or distinct CD4(+) T cells are involved in these responses has not been established. Here we describe two CD4(+) T cells, LLO118 and LLO56, specific for an immunodominant Listeria monocytogenes epitope, with dramatically different responses to primary and secondary infection. Comparing in vivo responses, LLO118 T cells proliferate more strongly to primary infection, whereas surprisingly, LLO56 has a superior CD4(+) recall response to secondary infection. LLO118 T cells provide more robust help for CD8(+) T-cell responses to secondary infection than LLO56. We found no detectable differences in antigen sensitivity, but naive LLO118 T cells have much lower levels of CD5 and their T-cell receptor levels are dramatically down-regulated after their strong primary response. Thus, distinct CD4(+) helper T cells are specialized to help either in primary or secondary responses to infection.
Duke Scholars
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- Sequence Homology, Amino Acid
- Molecular Sequence Data
- Mice, Transgenic
- Mice
- Listeria monocytogenes
- Epitopes
- Cell Proliferation
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Animals
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sequence Homology, Amino Acid
- Molecular Sequence Data
- Mice, Transgenic
- Mice
- Listeria monocytogenes
- Epitopes
- Cell Proliferation
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Animals