Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.
In signal transduction of metazoan cells, ion channels of the family of transient receptor potential (TRP) have been identified to respond to diverse external and internal stimuli, amongst them osmotic stimuli. This report highlights findings pertaining to the TRPV subfamily, focusing on mammalian members. Of the six mammalian TRPV channels, TRPV1, 2 and 4 were demonstrated to function in transduction of osmotic stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue osmosensory deficits of the TRPV mutant strain osm-9 in Caenorhabditis elegans, despite not more than 26% orthology of the respective proteins.
Duke Scholars
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Related Subject Headings
- TRPV Cation Channels
- Signal Transduction
- Physiology
- Osmosis
- Mice, Knockout
- Mice
- Mechanotransduction, Cellular
- Mammals
- Humans
- Homeostasis
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- TRPV Cation Channels
- Signal Transduction
- Physiology
- Osmosis
- Mice, Knockout
- Mice
- Mechanotransduction, Cellular
- Mammals
- Humans
- Homeostasis