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Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.

Publication ,  Journal Article
Leykin, Y; Christopher, PP; Holtzheimer, PE; Appelbaum, PS; Mayberg, HS; Lisanby, SH; Dunn, LB
Published in: AJOB Prim Res
October 2011

BACKGROUND: Deep brain stimulation (DBS) for treatment-resistant depression (TRD) is the focus of great interest and numerous studies. Given the state of this research, the risks of DBS, the uncertainty of direct benefits, and the potential for therapeutic misconception (TM), examination of research participants' perspectives is critical to addressing concerns about the adequacy of consent among people with TRD. METHODS: Among 31 participants considering DBS studies at two sites, self-report questionnaires were used to examine three dimensions of TM (eight true/false items). Additional Likert-scale items assessed perceptions of risks, potential benefits, and altruistic motivations. RESULTS: Participants correctly identified the surgery itself as the riskiest study procedure, although only four participants rated the surgery as "high risk." Most participants rated the entire DBS study as "moderate" or lower risk. Participants rated the likelihood of others benefiting in the future more strongly than they did the likelihood of personal benefit. Participants held positive attitudes toward research, and were moderately altruistic. Nearly two-thirds of the 31 participants (64.5%) answered at least one of the true/false TM items incorrectly. CONCLUSIONS: Individuals considering DBS studies for TRD demonstrated reasonable perceptions of risks and benefits, distinguished among procedural risks, and expressed hopes for personal benefit as well as altruism. Findings related to TM were mixed: Participants understood the experimental stage of DBS for depression and endorsed the possibility of no personal benefit, yet there was some evidence for TM. Although these findings are reassuring, investigators must nevertheless remain vigilant about identifying and addressing potential misconceptions.

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Published In

AJOB Prim Res

DOI

ISSN

2150-7716

Publication Date

October 2011

Volume

2

Issue

4

Start / End Page

33 / 41

Location

United States

Related Subject Headings

  • 2201 Applied Ethics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leykin, Y., Christopher, P. P., Holtzheimer, P. E., Appelbaum, P. S., Mayberg, H. S., Lisanby, S. H., & Dunn, L. B. (2011). Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception. AJOB Prim Res, 2(4), 33–41. https://doi.org/10.1080/21507716.2011.627579
Leykin, Yan, Paul P. Christopher, Paul E. Holtzheimer, Paul S. Appelbaum, Helen S. Mayberg, Sarah H. Lisanby, and Laura B. Dunn. “Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.AJOB Prim Res 2, no. 4 (October 2011): 33–41. https://doi.org/10.1080/21507716.2011.627579.
Leykin Y, Christopher PP, Holtzheimer PE, Appelbaum PS, Mayberg HS, Lisanby SH, et al. Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception. AJOB Prim Res. 2011 Oct;2(4):33–41.
Leykin, Yan, et al. “Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.AJOB Prim Res, vol. 2, no. 4, Oct. 2011, pp. 33–41. Pubmed, doi:10.1080/21507716.2011.627579.
Leykin Y, Christopher PP, Holtzheimer PE, Appelbaum PS, Mayberg HS, Lisanby SH, Dunn LB. Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception. AJOB Prim Res. 2011 Oct;2(4):33–41.

Published In

AJOB Prim Res

DOI

ISSN

2150-7716

Publication Date

October 2011

Volume

2

Issue

4

Start / End Page

33 / 41

Location

United States

Related Subject Headings

  • 2201 Applied Ethics