Skip to main content
Journal cover image

Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model.

Publication ,  Journal Article
Rowny, SB; Cycowicz, YM; McClintock, SM; Truesdale, MD; Luber, B; Lisanby, SH
Published in: Neuroimage
September 2009

Electroconvulsive therapy (ECT) is an effective treatment for severe depression; however, the induced therapeutic seizure acts on the autonomic nervous system and results in significant cardiac effects. This is an important consideration particularly in the elderly. Magnetic seizure therapy (MST) is in development as a less invasive alternative, but its effects on cardiac function have not been studied. We sought to model those effects in nonhuman primates to inform the development of safer neurostimulation interventions. Twenty four rhesus monkeys were randomly assigned to receive 6 weeks of daily treatment with electroconvulsive stimulation (ECS), magnetic seizure therapy (MST) or anesthesia-alone sham. Digitally acquired ECG and an automated R-wave and inter-R interval (IRI) sampling were used to measure intervention effects on heart rate (HR). Significant differences between experimental conditions were found in the HR as evidenced by changes in the immediate post-stimulus, ictal and postictal epochs. Immediate post-stimulus bradycardia was seen with ECS but not with MST. ECS induced significantly more tachycardia than MST or sham in both the ictal and postictal periods. MST resulted in a small, but statistically significant increase in HR during the postictal period relative to baseline. HR was found to increase by 25% and 8% in the ECS and MST conditions, respectively. MST resulted in significantly less marked sympathetic and parasympathetic response than did ECS. This differential physiological response is consistent with MST having a more superficial cortical site of action with less impact on deeper brain structures implicated in cardiac control relative to ECT. The clinical relevance of the topographical seizure spread of MST and its associated effects on the autonomic nervous system remain to be determined in human clinical trials.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

September 2009

Volume

47

Issue

3

Start / End Page

1086 / 1091

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Male
  • Magnetic Field Therapy
  • Macaca mulatta
  • Heart Rate
  • Female
  • Electroconvulsive Therapy
  • Electrocardiography
  • Animals
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rowny, S. B., Cycowicz, Y. M., McClintock, S. M., Truesdale, M. D., Luber, B., & Lisanby, S. H. (2009). Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model. Neuroimage, 47(3), 1086–1091. https://doi.org/10.1016/j.neuroimage.2009.05.070
Rowny, Stefan B., Yael M. Cycowicz, Shawn M. McClintock, Matthew D. Truesdale, Bruce Luber, and Sarah H. Lisanby. “Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model.Neuroimage 47, no. 3 (September 2009): 1086–91. https://doi.org/10.1016/j.neuroimage.2009.05.070.
Rowny SB, Cycowicz YM, McClintock SM, Truesdale MD, Luber B, Lisanby SH. Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model. Neuroimage. 2009 Sep;47(3):1086–91.
Rowny, Stefan B., et al. “Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model.Neuroimage, vol. 47, no. 3, Sept. 2009, pp. 1086–91. Pubmed, doi:10.1016/j.neuroimage.2009.05.070.
Rowny SB, Cycowicz YM, McClintock SM, Truesdale MD, Luber B, Lisanby SH. Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model. Neuroimage. 2009 Sep;47(3):1086–1091.
Journal cover image

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

September 2009

Volume

47

Issue

3

Start / End Page

1086 / 1091

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Male
  • Magnetic Field Therapy
  • Macaca mulatta
  • Heart Rate
  • Female
  • Electroconvulsive Therapy
  • Electrocardiography
  • Animals
  • 42 Health sciences