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Therapeutic application of repetitive transcranial magnetic stimulation: a review.

Publication ,  Journal Article
Wassermann, EM; Lisanby, SH
Published in: Clin Neurophysiol
August 2001

Transcranial magnetic stimulation (TMS), a non-invasive means of electrically stimulating neurons in the human cerebral cortex, is able to modify neuronal activity locally and at distant sites when delivered in series or trains of pulses. Data from stimulation of the motor cortex suggest that the type of effect on the excitability of the cortical network depends on the frequency of stimulation. These data, as well as results from studies in rodents, have been generalized across brain areas and species to provide rationales for using repetitive TMS (rTMS) to treat various brain disorders, most notably depression. Research into clinical applications for TMS remains active and has the potential to provide useful data, but, to date, the results of blinded, sham-controlled trials do not provide clear evidence of beneficial effects that replace or even match the effectiveness of conventional treatments in any disorder. In this review, we discuss the clinical and scientific bases for using rTMS as treatment, and review the results of trials in psychiatric and neurological disorders to date.

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Published In

Clin Neurophysiol

DOI

ISSN

1388-2457

Publication Date

August 2001

Volume

112

Issue

8

Start / End Page

1367 / 1377

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Rodentia
  • Prefrontal Cortex
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Nerve Net
  • Motor Cortex
  • Humans
  • Electroconvulsive Therapy
  • Electric Stimulation Therapy
 

Citation

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Wassermann, E. M., & Lisanby, S. H. (2001). Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin Neurophysiol, 112(8), 1367–1377. https://doi.org/10.1016/s1388-2457(01)00585-5
Wassermann, E. M., and S. H. Lisanby. “Therapeutic application of repetitive transcranial magnetic stimulation: a review.Clin Neurophysiol 112, no. 8 (August 2001): 1367–77. https://doi.org/10.1016/s1388-2457(01)00585-5.
Wassermann EM, Lisanby SH. Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin Neurophysiol. 2001 Aug;112(8):1367–77.
Wassermann, E. M., and S. H. Lisanby. “Therapeutic application of repetitive transcranial magnetic stimulation: a review.Clin Neurophysiol, vol. 112, no. 8, Aug. 2001, pp. 1367–77. Pubmed, doi:10.1016/s1388-2457(01)00585-5.
Wassermann EM, Lisanby SH. Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin Neurophysiol. 2001 Aug;112(8):1367–1377.
Journal cover image

Published In

Clin Neurophysiol

DOI

ISSN

1388-2457

Publication Date

August 2001

Volume

112

Issue

8

Start / End Page

1367 / 1377

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Rodentia
  • Prefrontal Cortex
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Nerve Net
  • Motor Cortex
  • Humans
  • Electroconvulsive Therapy
  • Electric Stimulation Therapy