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Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass.

Publication ,  Journal Article
Madden, JF; Burchette, JL; Raj, GV; Daly, JT; Tannenbaum, M
Published in: Urol Oncol
2005

Gastrointestinal stromal tumors (GIST) of the anterior rectal wall can present as a prostatic mass, with concomitant obstructive symptoms. Transrectal biopsies of GIST may be misdiagnosed as primary prostatic sarcomas. We report 3 cases of GIST that were initially characterized as prostatic leiomyosarcomas and treated definitively with pelvic exenteration. The correct diagnosis was possible only after immunohistochemical staining for CD117 and was made retrospectively in 2 of 3 cases. Additional therapy with imatinib (Gleevec, Novartis Pharmaceuticals Corporation, East Hanover, NJ), an inhibitor of CD117 tyrosine kinase activity, treated recurrence in one patient and effected complete remission.

Duke Scholars

Published In

Urol Oncol

DOI

ISSN

1078-1439

Publication Date

2005

Volume

23

Issue

4

Start / End Page

268 / 272

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Salvage Therapy
  • Rectal Neoplasms
  • Pyrimidines
  • Prostatic Neoplasms
  • Piperazines
  • Middle Aged
  • Male
  • Leiomyosarcoma
  • Immunohistochemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Madden, J. F., Burchette, J. L., Raj, G. V., Daly, J. T., & Tannenbaum, M. (2005). Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass. Urol Oncol, 23(4), 268–272. https://doi.org/10.1016/j.urolonc.2005.02.001
Madden, John F., James L. Burchette, Ganesh V. Raj, John T. Daly, and Myron Tannenbaum. “Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass.Urol Oncol 23, no. 4 (2005): 268–72. https://doi.org/10.1016/j.urolonc.2005.02.001.
Madden JF, Burchette JL, Raj GV, Daly JT, Tannenbaum M. Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass. Urol Oncol. 2005;23(4):268–72.
Madden, John F., et al. “Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass.Urol Oncol, vol. 23, no. 4, 2005, pp. 268–72. Pubmed, doi:10.1016/j.urolonc.2005.02.001.
Madden JF, Burchette JL, Raj GV, Daly JT, Tannenbaum M. Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass. Urol Oncol. 2005;23(4):268–272.
Journal cover image

Published In

Urol Oncol

DOI

ISSN

1078-1439

Publication Date

2005

Volume

23

Issue

4

Start / End Page

268 / 272

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Salvage Therapy
  • Rectal Neoplasms
  • Pyrimidines
  • Prostatic Neoplasms
  • Piperazines
  • Middle Aged
  • Male
  • Leiomyosarcoma
  • Immunohistochemistry