Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.
Publication
, Journal Article
Madison, R; da Silva, CF; Dikkes, P; Chiu, TH; Sidman, RL
Published in: Exp Neurol
June 1985
The sciatic nerve of adult mice was transected and proximal and distal nerve stumps were sutured into a nontoxic bioresorbable nerve guide. Nerve guide lumens were either empty or filled with a gel containing 80% laminin and additional extracellular matrix components. Two weeks later cells in the L3 through L5 dorsal root ganglia and the ventral horn of the spinal cord were retrogradely filled with horseradish peroxidase. All animals with the laminin-containing gel but none with empty nerve guides displayed labeled cells. This suggests that the laminin-containing gel significantly hastened axonal regeneration in vivo.
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Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
June 1985
Volume
88
Issue
3
Start / End Page
767 / 772
Location
United States
Related Subject Headings
- Sciatic Nerve
- Polymers
- Polyesters
- Neurology & Neurosurgery
- Nerve Regeneration
- Mice, Inbred C57BL
- Mice
- Male
- Laminin
- Lactic Acid
Citation
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Chicago
ICMJE
MLA
NLM
Madison, R., da Silva, C. F., Dikkes, P., Chiu, T. H., & Sidman, R. L. (1985). Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol, 88(3), 767–772. https://doi.org/10.1016/0014-4886(85)90087-1
Madison, R., C. F. da Silva, P. Dikkes, T. H. Chiu, and R. L. Sidman. “Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.” Exp Neurol 88, no. 3 (June 1985): 767–72. https://doi.org/10.1016/0014-4886(85)90087-1.
Madison R, da Silva CF, Dikkes P, Chiu TH, Sidman RL. Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol. 1985 Jun;88(3):767–72.
Madison, R., et al. “Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.” Exp Neurol, vol. 88, no. 3, June 1985, pp. 767–72. Pubmed, doi:10.1016/0014-4886(85)90087-1.
Madison R, da Silva CF, Dikkes P, Chiu TH, Sidman RL. Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol. 1985 Jun;88(3):767–772.
Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
June 1985
Volume
88
Issue
3
Start / End Page
767 / 772
Location
United States
Related Subject Headings
- Sciatic Nerve
- Polymers
- Polyesters
- Neurology & Neurosurgery
- Nerve Regeneration
- Mice, Inbred C57BL
- Mice
- Male
- Laminin
- Lactic Acid