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Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats.

Publication ,  Journal Article
Takahashi, T; Nakade, Y; Fukuda, H; Tsukamoto, K; Mantyh, C; Pappas, TN
Published in: Dig Dis Sci
May 2008

BACKGROUND: Stress and central corticotropin releasing factor (CRF) are contributing factors to the pathogenesis of irritable bowel syndrome (IBS). It has been shown that restraint stress and central CRF stimulate colonic motility in rats. Short-chain fatty acids (SCFAs) are produced by bacterial fermentation from dietary fibers. It is controversial whether daily intake of dietary fiber is beneficial for patients with diarrhea-predominant IBS. We studied whether dietary fiber intake affects colonic transit and motility stimulated by restraint stress and central CRF in rats. METHODS: Corn starch is digested almost completely in the small intestine, while potato starch shows substantial resistance to alpha-amylase and its consumption leads to stimulation of large-bowel fermentation. Four weeks after a corn starch, potato starch, or usual diet (rat chow), colonic transit and motility stimulated by restraint stress and intracisternal (ic) injection of CRF were studied. Fecal concentration of SCFAs in the cecum was measured by high-performance liquid chromatography (HPLC). RESULTS: Four-week treatment with potato starch diet significantly increased cecal concentrations of SCFAs, compared to treatment with corn starch diet. Accelerated colonic transit induced by stress and ic injection of CRF (1 microg) were significantly attenuated in rats receiving potato starch diet compared to rats receiving corn starch diet. The incidence of unformed stool (diarrhea) induced by stress and CRF was also reduced in rats receiving potato starch diet compared to rats receiving corn starch diet and usual diet. CONCLUSION: It is suggested that daily intake of a high-fiber diet may prevent stress- and CRF-induced acceleration of colonic transit and diarrhea. This study may contribute to treatment for the patients of diarrhea-predominant IBS.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

May 2008

Volume

53

Issue

5

Start / End Page

1271 / 1277

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Starch
  • Restraint, Physical
  • Rats, Sprague-Dawley
  • Rats
  • Male
  • Irritable Bowel Syndrome
  • Gastrointestinal Transit
  • Gastroenterology & Hepatology
  • Dietary Fiber
 

Citation

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Takahashi, T., Nakade, Y., Fukuda, H., Tsukamoto, K., Mantyh, C., & Pappas, T. N. (2008). Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats. Dig Dis Sci, 53(5), 1271–1277. https://doi.org/10.1007/s10620-008-0228-8
Takahashi, Toku, Yukiomi Nakade, Hiroyuki Fukuda, Kiyoshi Tsukamoto, Christopher Mantyh, and Theodore N. Pappas. “Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats.Dig Dis Sci 53, no. 5 (May 2008): 1271–77. https://doi.org/10.1007/s10620-008-0228-8.
Takahashi T, Nakade Y, Fukuda H, Tsukamoto K, Mantyh C, Pappas TN. Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats. Dig Dis Sci. 2008 May;53(5):1271–7.
Takahashi, Toku, et al. “Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats.Dig Dis Sci, vol. 53, no. 5, May 2008, pp. 1271–77. Pubmed, doi:10.1007/s10620-008-0228-8.
Takahashi T, Nakade Y, Fukuda H, Tsukamoto K, Mantyh C, Pappas TN. Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats. Dig Dis Sci. 2008 May;53(5):1271–1277.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

May 2008

Volume

53

Issue

5

Start / End Page

1271 / 1277

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Starch
  • Restraint, Physical
  • Rats, Sprague-Dawley
  • Rats
  • Male
  • Irritable Bowel Syndrome
  • Gastrointestinal Transit
  • Gastroenterology & Hepatology
  • Dietary Fiber