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Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.

Publication ,  Journal Article
Gianfrancesco, F; Cannella, M; Martino, T; Maglione, V; Esposito, T; Innocenzi, G; Vitale, E; Liquori, CL; Marchuk, DA; Squitieri, F
Published in: Am J Med Genet B Neuropsychiatr Genet
July 5, 2007

Cavernous vascular malformations may affect brain and out-of-brain tissues. In most cases, cerebral cavernous malformations (CCMs) involve the brain alone, and are rarely associated with skin hemangiomas, spinal cord, retinal, hepatic or vertebral lesions. CCMs can cause seizures, intracranial and spinal haemorrhages, focal neurological deficits, and migraine-like headaches. After collecting CCM families of Italian origin and investigating the genetic basis of the disorder we disclosed two novel molecular variations in the KRIT1 and MGC4607 genes. We found a novel CCM1 gene mutation (Q66X) in a family with apparently asymptomatic old-aged mutation carriers and patients who either had skin angiomas alone or the full association of cerebral, spinal, and skin lesions. In this family we report the highest variability in mutation penetrance so far described, including the presence of CCM in one subject since birth (surgery at 19 months of age), a condition to our knowledge so far unreported. In a CCM2 affected family, we also report a novel causative mutation, (54_55delAC) in exon 2 of the MGC4607 gene, that produces a truncated protein containing only 22 amino acids. These data describe novel CCM mutations associated with a particularly high variability of the penetrance causing, in some cases, reduced expression of clinical symptoms and sporadic cases with apparent negative family history. Hence they emphasize the importance of DNA-based diagnostics and genetic counseling to identify unaffected mutation carriers subjects, even at advanced age.

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Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

July 5, 2007

Volume

144B

Issue

5

Start / End Page

691 / 695

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins
  • Penetrance
  • Pedigree
  • Mutation
  • Middle Aged
  • Microtubule-Associated Proteins
  • Male
  • KRIT1 Protein
  • Italy
  • Humans
 

Citation

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Gianfrancesco, F., Cannella, M., Martino, T., Maglione, V., Esposito, T., Innocenzi, G., … Squitieri, F. (2007). Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. Am J Med Genet B Neuropsychiatr Genet, 144B(5), 691–695. https://doi.org/10.1002/ajmg.b.30381
Gianfrancesco, Fernando, Milena Cannella, Tiziana Martino, Vittorio Maglione, Teresa Esposito, Gualtiero Innocenzi, Emilia Vitale, Christina L. Liquori, Douglas A. Marchuk, and Ferdinando Squitieri. “Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.Am J Med Genet B Neuropsychiatr Genet 144B, no. 5 (July 5, 2007): 691–95. https://doi.org/10.1002/ajmg.b.30381.
Gianfrancesco F, Cannella M, Martino T, Maglione V, Esposito T, Innocenzi G, et al. Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):691–5.
Gianfrancesco, Fernando, et al. “Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.Am J Med Genet B Neuropsychiatr Genet, vol. 144B, no. 5, July 2007, pp. 691–95. Pubmed, doi:10.1002/ajmg.b.30381.
Gianfrancesco F, Cannella M, Martino T, Maglione V, Esposito T, Innocenzi G, Vitale E, Liquori CL, Marchuk DA, Squitieri F. Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):691–695.
Journal cover image

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

July 5, 2007

Volume

144B

Issue

5

Start / End Page

691 / 695

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins
  • Penetrance
  • Pedigree
  • Mutation
  • Middle Aged
  • Microtubule-Associated Proteins
  • Male
  • KRIT1 Protein
  • Italy
  • Humans