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Primary systemic therapy in breast cancer: past lessons and new approaches.

Publication ,  Journal Article
Herold, CI; Marcom, PK
Published in: Cancer Invest
December 2008

Primary systemic therapy (PST) is a common treatment strategy used to optimize surgical outcomes for women with locally advanced breast cancer. Several cooperative group trials have shown equivalent survival outcomes between neoadjuvant and adjuvant chemotherapy and have identified pathologic complete response (pCR) as a biologic marker for survival. Research efforts to optimize PST include the development of strategies to predict individual response and to guide the choice of chemotherapy. These emerging approaches are informed by our knowledge of subtypes of breast cancer, as well as genomic technologies, such as chemosensitivity signatures. Following definitive surgery, the management of residual disease is controversial.

Duke Scholars

Published In

Cancer Invest

DOI

EISSN

1532-4192

Publication Date

December 2008

Volume

26

Issue

10

Start / End Page

1052 / 1059

Location

England

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Prognosis
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Invasiveness
  • Humans
  • Female
  • Combined Modality Therapy
 

Citation

APA
Chicago
ICMJE
MLA
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Herold, C. I., & Marcom, P. K. (2008). Primary systemic therapy in breast cancer: past lessons and new approaches. Cancer Invest, 26(10), 1052–1059. https://doi.org/10.1080/07357900802123260
Herold, Christina I., and P Kelly Marcom. “Primary systemic therapy in breast cancer: past lessons and new approaches.Cancer Invest 26, no. 10 (December 2008): 1052–59. https://doi.org/10.1080/07357900802123260.
Herold CI, Marcom PK. Primary systemic therapy in breast cancer: past lessons and new approaches. Cancer Invest. 2008 Dec;26(10):1052–9.
Herold, Christina I., and P. Kelly Marcom. “Primary systemic therapy in breast cancer: past lessons and new approaches.Cancer Invest, vol. 26, no. 10, Dec. 2008, pp. 1052–59. Pubmed, doi:10.1080/07357900802123260.
Herold CI, Marcom PK. Primary systemic therapy in breast cancer: past lessons and new approaches. Cancer Invest. 2008 Dec;26(10):1052–1059.

Published In

Cancer Invest

DOI

EISSN

1532-4192

Publication Date

December 2008

Volume

26

Issue

10

Start / End Page

1052 / 1059

Location

England

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Prognosis
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Invasiveness
  • Humans
  • Female
  • Combined Modality Therapy