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Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B.

Publication ,  Journal Article
Polite, BN; Cirrincione, C; Fleming, GF; Berry, DA; Seidman, A; Muss, H; Norton, L; Shapiro, C; Bakri, K; Marcom, K; Lake, D; Schwartz, JH ...
Published in: J Clin Oncol
June 1, 2008

PURPOSE: African American women are more likely to be diagnosed with metastatic breast cancer at the time of presentation than whites, and have shorter survival once diagnosed. This study examines racial differences in clinical outcomes in the setting of two large cooperative group randomized clinical trials. PATIENTS AND METHODS: The study cohort consisted of 787 white (80%) and 195 African American (20%) patients with metastatic breast cancer enrolled in two successive Cancer and Leukemia Group B (CALGB) trials using taxanes in the metastatic setting. Differences in overall survival (OS), response incidence, and time to treatment failure (TTF) were examined by race. In addition, differences in the incidence of baseline and treatment-related toxicities were examined. RESULTS: With 779 deaths (166 African Americans and 613 whites), median OS was 14.3 months for African Americans and 18.75 months for whites (hazard ratio [HR] = 1.37; 95% CI, 1.15 to 1.63). When adjusted for prognostic factors, African Americans had a 24% increase in the hazard of death compared with whites (HR = 1.24; 95% CI, 1.02 to 1.51). No significant differences in TTF or overall response to therapy were seen. No clinically significant toxicity differences were seen. CONCLUSION: African Americans with metastatic breast cancer have an increased hazard of death compared with whites despite the receipt of similar per-protocol treatment, but experience no differences in TTF or overall response to therapy. We hypothesize that more direct and robust measures of comorbidities, and perhaps other factors such as receipt of subsequent therapy could help further explain the observed survival difference.

Duke Scholars

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

June 1, 2008

Volume

26

Issue

16

Start / End Page

2659 / 2665

Location

United States

Related Subject Headings

  • White People
  • Treatment Failure
  • Time Factors
  • Survival Analysis
  • Randomized Controlled Trials as Topic
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Multicenter Studies as Topic
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Polite, B. N., Cirrincione, C., Fleming, G. F., Berry, D. A., Seidman, A., Muss, H., … Winer, E. P. (2008). Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B. J Clin Oncol, 26(16), 2659–2665. https://doi.org/10.1200/JCO.2007.13.9782
Polite, Blase N., Constance Cirrincione, Gini F. Fleming, Donald A. Berry, Andrew Seidman, Hyman Muss, Larry Norton, et al. “Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B.J Clin Oncol 26, no. 16 (June 1, 2008): 2659–65. https://doi.org/10.1200/JCO.2007.13.9782.
Polite BN, Cirrincione C, Fleming GF, Berry DA, Seidman A, Muss H, et al. Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B. J Clin Oncol. 2008 Jun 1;26(16):2659–65.
Polite, Blase N., et al. “Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B.J Clin Oncol, vol. 26, no. 16, June 2008, pp. 2659–65. Pubmed, doi:10.1200/JCO.2007.13.9782.
Polite BN, Cirrincione C, Fleming GF, Berry DA, Seidman A, Muss H, Norton L, Shapiro C, Bakri K, Marcom K, Lake D, Schwartz JH, Hudis C, Winer EP. Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B. J Clin Oncol. 2008 Jun 1;26(16):2659–2665.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

June 1, 2008

Volume

26

Issue

16

Start / End Page

2659 / 2665

Location

United States

Related Subject Headings

  • White People
  • Treatment Failure
  • Time Factors
  • Survival Analysis
  • Randomized Controlled Trials as Topic
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Multicenter Studies as Topic
  • Middle Aged