Triple reuptake inhibitors: the next generation of antidepressants.
Depression has been associated with impaired neurotransmission of serotonergic, norepinephrinergic, and dopaminergic pathways, although most pharmacologic treatment strategies for depression enhance only serotonin and norepinephrine neurotransmission. Current drug development efforts are aimed at a new class of antidepressants which inhibit the reuptake of all three neurotransmitters in the hope of creating medications with broader efficacy and/or quicker onset of action. The current review explores limitations of presently available antidepressants and the history and premise behind the movement to devise triple reuptake inhibitors. The evidence for and against the claim that broader spectrum agents are more efficacious is discussed. Examples of triple reuptake inhibitors in development are compared, and preclinical and clinical research with these agents to date is described.
Duke Scholars
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- Neurology & Neurosurgery
- 5202 Biological psychology
- 3214 Pharmacology and pharmaceutical sciences
- 3209 Neurosciences
- 1701 Psychology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1109 Neurosciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neurology & Neurosurgery
- 5202 Biological psychology
- 3214 Pharmacology and pharmaceutical sciences
- 3209 Neurosciences
- 1701 Psychology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1109 Neurosciences