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SR1, a mouse odorant receptor with an unusually broad response profile.

Publication ,  Journal Article
Grosmaitre, X; Fuss, SH; Lee, AC; Adipietro, KA; Matsunami, H; Mombaerts, P; Ma, M
Published in: J Neurosci
November 18, 2009

The current consensus model in mammalian olfaction is that the detection of millions of odorants requires a large number of odorant receptors (ORs) and that each OR interacts selectively with a small subset of odorants, which are typically related in structure. Here, we report the odorant response properties of an OR that deviates from this model: SR1, a mouse OR that is abundantly expressed in sensory neurons of the septal organ and also of the main olfactory epithelium. Patch-clamp recordings reveal that olfactory sensory neurons (OSNs) that express SR1 respond to many, structurally unrelated odorants, and over a wide concentration range. Most OSNs expressing a gene-targeted SR1 locus that lacks the SR1 coding sequence do not show this broad responsiveness. Gene transfer in the heterologous expression system Hana3A confirms the broad response profile of SR1. There may be other mouse ORs with such broad response profiles.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

November 18, 2009

Volume

29

Issue

46

Start / End Page

14545 / 14552

Location

United States

Related Subject Headings

  • Smell
  • Receptors, Odorant
  • Reaction Time
  • Neurology & Neurosurgery
  • Models, Neurological
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Gene Targeting
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grosmaitre, X., Fuss, S. H., Lee, A. C., Adipietro, K. A., Matsunami, H., Mombaerts, P., & Ma, M. (2009). SR1, a mouse odorant receptor with an unusually broad response profile. J Neurosci, 29(46), 14545–14552. https://doi.org/10.1523/JNEUROSCI.2752-09.2009
Grosmaitre, Xavier, Stefan H. Fuss, Anderson C. Lee, Kaylin A. Adipietro, Hiroaki Matsunami, Peter Mombaerts, and Minghong Ma. “SR1, a mouse odorant receptor with an unusually broad response profile.J Neurosci 29, no. 46 (November 18, 2009): 14545–52. https://doi.org/10.1523/JNEUROSCI.2752-09.2009.
Grosmaitre X, Fuss SH, Lee AC, Adipietro KA, Matsunami H, Mombaerts P, et al. SR1, a mouse odorant receptor with an unusually broad response profile. J Neurosci. 2009 Nov 18;29(46):14545–52.
Grosmaitre, Xavier, et al. “SR1, a mouse odorant receptor with an unusually broad response profile.J Neurosci, vol. 29, no. 46, Nov. 2009, pp. 14545–52. Pubmed, doi:10.1523/JNEUROSCI.2752-09.2009.
Grosmaitre X, Fuss SH, Lee AC, Adipietro KA, Matsunami H, Mombaerts P, Ma M. SR1, a mouse odorant receptor with an unusually broad response profile. J Neurosci. 2009 Nov 18;29(46):14545–14552.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

November 18, 2009

Volume

29

Issue

46

Start / End Page

14545 / 14552

Location

United States

Related Subject Headings

  • Smell
  • Receptors, Odorant
  • Reaction Time
  • Neurology & Neurosurgery
  • Models, Neurological
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Gene Targeting