Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
Publication
, Journal Article
Clancy, KW; Melvin, JA; McCafferty, DG
Published in: Biopolymers
January 2010
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.
Duke Scholars
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Published In
Biopolymers
DOI
EISSN
1097-0282
ISSN
0006-3525
Publication Date
January 2010
Volume
94
Issue
4
Start / End Page
385 / 396
Related Subject Headings
- Substrate Specificity
- Gram-Positive Bacteria
- Enzyme Inhibitors
- Drug Resistance, Bacterial
- Cysteine Endopeptidases
- Biophysics
- Bacterial Proteins
- Anti-Bacterial Agents
- Aminoacyltransferases
- 34 Chemical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Clancy, K. W., Melvin, J. A., & McCafferty, D. G. (2010). Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. Biopolymers, 94(4), 385–396. https://doi.org/10.1002/bip.21472
Clancy, Kathleen W., Jeffrey A. Melvin, and Dewey G. McCafferty. “Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.” Biopolymers 94, no. 4 (January 2010): 385–96. https://doi.org/10.1002/bip.21472.
Clancy KW, Melvin JA, McCafferty DG. Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. Biopolymers. 2010 Jan;94(4):385–96.
Clancy, Kathleen W., et al. “Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.” Biopolymers, vol. 94, no. 4, Jan. 2010, pp. 385–96. Epmc, doi:10.1002/bip.21472.
Clancy KW, Melvin JA, McCafferty DG. Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. Biopolymers. 2010 Jan;94(4):385–396.
Published In
Biopolymers
DOI
EISSN
1097-0282
ISSN
0006-3525
Publication Date
January 2010
Volume
94
Issue
4
Start / End Page
385 / 396
Related Subject Headings
- Substrate Specificity
- Gram-Positive Bacteria
- Enzyme Inhibitors
- Drug Resistance, Bacterial
- Cysteine Endopeptidases
- Biophysics
- Bacterial Proteins
- Anti-Bacterial Agents
- Aminoacyltransferases
- 34 Chemical sciences