Skip to main content

Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII.

Publication ,  Journal Article
Malkova, A; Swanson, J; German, M; McCusker, JH; Housworth, EA; Stahl, FW; Haber, JE
Published in: Genetics
September 2004

Gene conversions and crossing over were analyzed along 10 intervals in a 405-kb region comprising nearly all of the left arm of chromosome VII in Saccharomyces cerevisiae. Crossover interference was detected in all intervals as measured by a reduced number of nonparental ditypes. We have evaluated interference between crossovers in adjacent intervals by methods that retain the information contained in tetrads as opposed to single segregants. Interference was seen between intervals when the distance in the region adjacent to a crossover was < approximately 35 cM (90 kb). At the met13 locus, which exhibits approximately 9% gene conversions, those gene conversions accompanied by crossing over exerted interference in exchanges in an adjacent interval, whereas met13 gene conversions without an accompanying exchange did not show interference. The pattern of exchanges along this chromosome arm can be represented by a counting model in which there are three nonexchange events between adjacent exchanges; however, maximum-likelihood analysis suggests that approximately 8-12% of the crossovers on chromosome VII arise by a separate, noninterfering mechanism.

Duke Scholars

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

September 2004

Volume

168

Issue

1

Start / End Page

49 / 63

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae
  • Models, Genetic
  • Likelihood Functions
  • Genetic Markers
  • Gene Conversion
  • Developmental Biology
  • Crossing Over, Genetic
  • Chromosomes, Fungal
  • Chromosome Mapping
  • 3105 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Malkova, A., Swanson, J., German, M., McCusker, J. H., Housworth, E. A., Stahl, F. W., & Haber, J. E. (2004). Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII. Genetics, 168(1), 49–63. https://doi.org/10.1534/genetics.104.027961
Malkova, Anna, Johanna Swanson, Miriam German, John H. McCusker, Elizabeth A. Housworth, Franklin W. Stahl, and James E. Haber. “Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII.Genetics 168, no. 1 (September 2004): 49–63. https://doi.org/10.1534/genetics.104.027961.
Malkova A, Swanson J, German M, McCusker JH, Housworth EA, Stahl FW, et al. Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII. Genetics. 2004 Sep;168(1):49–63.
Malkova, Anna, et al. “Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII.Genetics, vol. 168, no. 1, Sept. 2004, pp. 49–63. Pubmed, doi:10.1534/genetics.104.027961.
Malkova A, Swanson J, German M, McCusker JH, Housworth EA, Stahl FW, Haber JE. Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII. Genetics. 2004 Sep;168(1):49–63.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

September 2004

Volume

168

Issue

1

Start / End Page

49 / 63

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae
  • Models, Genetic
  • Likelihood Functions
  • Genetic Markers
  • Gene Conversion
  • Developmental Biology
  • Crossing Over, Genetic
  • Chromosomes, Fungal
  • Chromosome Mapping
  • 3105 Genetics