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COMT158 polymorphism and hostility.

Publication ,  Journal Article
Volavka, J; Kennedy, JL; Ni, X; Czobor, P; Nolan, K; Sheitman, B; Lindenmayer, J-P; Citrome, L; McEvoy, J; Lieberman, JA
Published in: Am J Med Genet B Neuropsychiatr Genet
May 15, 2004

The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.

Duke Scholars

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

May 15, 2004

Volume

127B

Issue

1

Start / End Page

28 / 29

Location

United States

Related Subject Headings

  • Valine
  • Schizophrenic Psychology
  • Schizophrenia
  • Risperidone
  • Polymorphism, Genetic
  • Olanzapine
  • Methionine
  • Humans
  • Hostility
  • Haloperidol
 

Citation

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Volavka, J., Kennedy, J. L., Ni, X., Czobor, P., Nolan, K., Sheitman, B., … Lieberman, J. A. (2004). COMT158 polymorphism and hostility. Am J Med Genet B Neuropsychiatr Genet, 127B(1), 28–29. https://doi.org/10.1002/ajmg.b.20149
Volavka, Jan, James L. Kennedy, Xingqun Ni, Pal Czobor, Karen Nolan, Brian Sheitman, Jean-Pierre Lindenmayer, Leslie Citrome, Joseph McEvoy, and Jeffrey A. Lieberman. “COMT158 polymorphism and hostility.Am J Med Genet B Neuropsychiatr Genet 127B, no. 1 (May 15, 2004): 28–29. https://doi.org/10.1002/ajmg.b.20149.
Volavka J, Kennedy JL, Ni X, Czobor P, Nolan K, Sheitman B, et al. COMT158 polymorphism and hostility. Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):28–9.
Volavka, Jan, et al. “COMT158 polymorphism and hostility.Am J Med Genet B Neuropsychiatr Genet, vol. 127B, no. 1, May 2004, pp. 28–29. Pubmed, doi:10.1002/ajmg.b.20149.
Volavka J, Kennedy JL, Ni X, Czobor P, Nolan K, Sheitman B, Lindenmayer J-P, Citrome L, McEvoy J, Lieberman JA. COMT158 polymorphism and hostility. Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):28–29.
Journal cover image

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

May 15, 2004

Volume

127B

Issue

1

Start / End Page

28 / 29

Location

United States

Related Subject Headings

  • Valine
  • Schizophrenic Psychology
  • Schizophrenia
  • Risperidone
  • Polymorphism, Genetic
  • Olanzapine
  • Methionine
  • Humans
  • Hostility
  • Haloperidol