Lipophilic peptides for gene delivery.
Publication
, Journal Article
Prata, CAH; Zhang, X-X; Luo, D; McIntosh, TJ; Barthelemy, P; Grinstaff, MW
Published in: Bioconjug Chem
February 2008
DNA transfections are widely performed in research laboratories and in vivo gene delivery holds the promise for curing many diseases. The synthetic carriers or vectors for DNA are typically cationic lipids. However, in biology, the recognition of nucleic acids by proteins involves both electrostatic and stacking contributions. As such we have prepared a series of new lipophilic peptide vectors that possess lysine and tryptophan amino acids for evaluation. These lipophilic peptides show minimal cytotoxicity and enhanced in vitro gene transfection activity.
Duke Scholars
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Published In
Bioconjug Chem
DOI
ISSN
1043-1802
Publication Date
February 2008
Volume
19
Issue
2
Start / End Page
418 / 420
Location
United States
Related Subject Headings
- Peptides
- Organic Chemistry
- Gene Transfer Techniques
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Prata, C. A. H., Zhang, X.-X., Luo, D., McIntosh, T. J., Barthelemy, P., & Grinstaff, M. W. (2008). Lipophilic peptides for gene delivery. Bioconjug Chem, 19(2), 418–420. https://doi.org/10.1021/bc700451b
Prata, Carla A. H., Xiao-Xiang Zhang, Dan Luo, Thomas J. McIntosh, Philippe Barthelemy, and Mark W. Grinstaff. “Lipophilic peptides for gene delivery.” Bioconjug Chem 19, no. 2 (February 2008): 418–20. https://doi.org/10.1021/bc700451b.
Prata CAH, Zhang X-X, Luo D, McIntosh TJ, Barthelemy P, Grinstaff MW. Lipophilic peptides for gene delivery. Bioconjug Chem. 2008 Feb;19(2):418–20.
Prata, Carla A. H., et al. “Lipophilic peptides for gene delivery.” Bioconjug Chem, vol. 19, no. 2, Feb. 2008, pp. 418–20. Pubmed, doi:10.1021/bc700451b.
Prata CAH, Zhang X-X, Luo D, McIntosh TJ, Barthelemy P, Grinstaff MW. Lipophilic peptides for gene delivery. Bioconjug Chem. 2008 Feb;19(2):418–420.
Published In
Bioconjug Chem
DOI
ISSN
1043-1802
Publication Date
February 2008
Volume
19
Issue
2
Start / End Page
418 / 420
Location
United States
Related Subject Headings
- Peptides
- Organic Chemistry
- Gene Transfer Techniques
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry