Scholars@Duke

Non-viral charge reversal vectors for pDNA delivery.

Publication ,  Journal Article
Prata, CAH; Li, Y; Luo, D; McIntosh, TJ; Grinstaff, MW
Published in: Conf Proc IEEE Eng Med Biol Soc
2006
Published version (DOI) Link to item

A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids.

Duke Scholars

Thomas James McIntosh
Author Thomas James McIntosh Cell Biology

Published In

Conf Proc IEEE Eng Med Biol Soc

DOI

10.1109/IEMBS.2006.260181

ISSN

1557-170X

Publication Date

2006

Volume

2006

Start / End Page

4347 / 4349

Location

United States

Related Subject Headings

  • X-Ray Diffraction
  • Scattering, Radiation
  • Microscopy, Electron, Transmission
  • Lipids
  • Light
  • K562 Cells
  • Humans
  • Genetic Vectors
  • Gene Transfer Techniques
  • DNA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Prata, C. A. H., Li, Y., Luo, D., McIntosh, T. J., & Grinstaff, M. W. (2006). Non-viral charge reversal vectors for pDNA delivery. Conf Proc IEEE Eng Med Biol Soc, 2006, 4347–4349. https://doi.org/10.1109/IEMBS.2006.260181
Prata, Carla A. H., Yougen Li, Dan Luo, Thomas J. McIntosh, and Mark W. Grinstaff. “Non-viral charge reversal vectors for pDNA delivery.” Conf Proc IEEE Eng Med Biol Soc 2006 (2006): 4347–49. https://doi.org/10.1109/IEMBS.2006.260181.
Prata CAH, Li Y, Luo D, McIntosh TJ, Grinstaff MW. Non-viral charge reversal vectors for pDNA delivery. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:4347–9.
Prata, Carla A. H., et al. “Non-viral charge reversal vectors for pDNA delivery.” Conf Proc IEEE Eng Med Biol Soc, vol. 2006, 2006, pp. 4347–49. Pubmed, doi:10.1109/IEMBS.2006.260181.
Prata CAH, Li Y, Luo D, McIntosh TJ, Grinstaff MW. Non-viral charge reversal vectors for pDNA delivery. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:4347–4349.

Published In

Conf Proc IEEE Eng Med Biol Soc

DOI

10.1109/IEMBS.2006.260181

ISSN

1557-170X

Publication Date

2006

Volume

2006

Start / End Page

4347 / 4349

Location

United States

Related Subject Headings

  • X-Ray Diffraction
  • Scattering, Radiation
  • Microscopy, Electron, Transmission
  • Lipids
  • Light
  • K562 Cells
  • Humans
  • Genetic Vectors
  • Gene Transfer Techniques
  • DNA