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Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model.

Publication ,  Journal Article
Kotloski, R; McNamara, JO
Published in: Hippocampus
June 2010

Elucidating the mechanisms of epileptogenesis in molecular terms can identify targets for therapies aimed at preventing epileptogenesis or limiting its progression. Genetic perturbations have implicated signaling by the neurotrophin, BDNF, and its receptor, TrkB, in limbic epileptogenesis. Whether this signaling is critical to epileptogenesis in the adult brain is unclear. We sought to determine whether reduced expression of TrkB de novo in the mature brain is sufficient to impair epileptogenesis in the kindling model. Treatment of adult Act-CreER TrkB(flox/flox) mice with tamoxifen resulted in modest reductions of TrkB protein expression de novo in the adult that were detected in hippocampus but not other brain regions. Modest reduction of hippocampal TrkB content inhibited epileptogenesis induced by stimulation of hippocampus or amygdala. The data support the conclusion that reduction of TrkB expression in hippocampus de novo in the mature brain impairs epileptogenesis in the kindling model. These findings advance TrkB and its downstream signaling pathways as attractive targets for limiting the progression of epileptogenesis.

Duke Scholars

Published In

Hippocampus

DOI

EISSN

1098-1063

Publication Date

June 2010

Volume

20

Issue

6

Start / End Page

713 / 723

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptor, trkB
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Kindling, Neurologic
  • Immunoblotting
  • Hippocampus
  • Epilepsy
  • Disease Models, Animal
 

Citation

APA
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ICMJE
MLA
NLM
Kotloski, R., & McNamara, J. O. (2010). Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model. Hippocampus, 20(6), 713–723. https://doi.org/10.1002/hipo.20673
Kotloski, Robert, and James O. McNamara. “Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model.Hippocampus 20, no. 6 (June 2010): 713–23. https://doi.org/10.1002/hipo.20673.
Kotloski, Robert, and James O. McNamara. “Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model.Hippocampus, vol. 20, no. 6, June 2010, pp. 713–23. Pubmed, doi:10.1002/hipo.20673.
Journal cover image

Published In

Hippocampus

DOI

EISSN

1098-1063

Publication Date

June 2010

Volume

20

Issue

6

Start / End Page

713 / 723

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptor, trkB
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Kindling, Neurologic
  • Immunoblotting
  • Hippocampus
  • Epilepsy
  • Disease Models, Animal